Evidence map›Paper›PMID 42518765›Full record

ArticleFrontiers in bioengineering and biotechnology2026

Synthetic biology and genome engineering in support of human, agricultural, and environmental security.

Carolyn Riley Chapman, Julie Trolle, Dominika Daria Wawrzyniak, Jef D Boeke, Ran Brosh

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Carolyn Riley ChapmanThe Multi-Regional Clinical Trials Center of Brigham and Women's Hospital and Harvard, Boston, MA, United States.
Julie TrolleDepartment of Genome Sciences, University of Washington, Seattle, WA, United States.
Dominika Daria WawrzyniakInstitute for Systems Genetics, NYU Langone Health, New York, NY, United States.
Jef D BoekeInstitute for Systems Genetics, NYU Langone Health, New York, NY, United States.
Ran BroshInstitute for Systems Genetics, NYU Langone Health, New York, NY, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid pace of innovation in synthetic biology and genome engineering elicits a need to reevaluate systems of oversight to ensure that biosafety and biosecurity safeguards are keeping up. Accordingly, the regulation of nucleic acid synthesis, an enabling technology for synthetic biology and genome engineering, is a current focus of political debate in the United States. However, to develop appropriate governance that neither under- nor overregulates technological development, policy leaders must also appreciate how advances in synthetic biology and genome engineering are being employed in the interests of biosecurity to support human health, manufacturing, food security, ecosystems and the natural environment. Synthetic biology can support the development of new therapeutics and health technologies, alternative biomanufacturing methodologies, food and agricultural innovations, environmental biosensors for monitoring infectious and toxic agents, and interventions aimed at preserving and restoring our natural environment. This Perspective provides an overview of current and potential benefits of synthetic biology and genome engineering, aiming to balance the broader societal discussion of potential risks-particularly in this special issue of the journal-with potential social, economic, and environmental value to individuals and society at large.

Indexed as

biomanufacturingbioremediationbiosecuritybiosensingbiotherapeuticsgenome engineeringnucleic acid synthesissynthetic biology

Identifiers

PMID42518765
PMCPMC13381746

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.