Evidence map›Paper›PMID 42518733›Full record

ArticleNeurobiology of sleep and circadian rhythms2026

Molecular correlates of sleep deprivation in the mouse brain identified by meta-analysis of microarray data.

Osama H M H Abdalla, Ella Dunlop, Tatiana S Wilson, Paul K Reardon, Mudassar Iqbal, Shu K E Tam, Vladyslav V Vyazovskiy, David W Ray, Laurence A Brown, Hai-Ying Mary Cheng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of sleep and circadian rhythms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Osama H M H AbdallaDepartment of Biology, University of Toronto Mississauga, Mississauga, ON, L5L 1C6, Canada.
Ella DunlopSleep and Circadian Neuroscience Institute (SCNi), Kavli Institute of Nanoscience Discovery, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom.
Tatiana S WilsonSleep and Circadian Neuroscience Institute (SCNi), NIHR Oxford Health Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom.
Paul K ReardonSection on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, Bethesda, MD, 20892, USA.
Mudassar IqbalDivision of Informatics, Imaging & Data Sciences, University of Manchester, United Kingdom.
Shu K E TamDuke Kunshan University (DKU), Kunshan, Jiangsu, China.
Vladyslav V VyazovskiySleep and Circadian Neuroscience Institute (SCNi), Kavli Institute of Nanoscience Discovery, Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom.
David W RaySleep and Circadian Neuroscience Institute (SCNi), NIHR Oxford Health Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom.
Laurence A BrownResearch IT, IT Services, University of Oxford, United Kingdom.
Hai-Ying Mary ChengDepartment of Biology, University of Toronto Mississauga, Mississauga, ON, L5L 1C6, Canada.
Stuart N PeirsonSleep and Circadian Neuroscience Institute (SCNi), Kavli Institute of Nanoscience Discovery, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studying the transcriptional changes in the brain following sleep deprivation has provided insight into the molecular mechanisms that differ between sleep and wake. Individual studies are limited in their ability to detect differentially expressed genes due to small sample size. Here we performed a meta-analysis of published brain expression data, totalling 173 microarrays across 245 mice. 498 genes were identified as significantly changing with sleep-deprivation at q < 0.01, 96 of which were previously identified by the original studies. Of the remaining 402 novel candidate sleep genes, 14 were associated with human sleep traits and 3 with sleep phenotypes in knockout mice. Candidate gene validation showed significant upregulation of

Indexed as

Meta-analysisRasd1Sleep deprivation

Identifiers

PMID42518733
PMCPMC13382439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.