Evidence map›Paper›PMID 42518678›Full record

ReviewFrontiers in systems neuroscience2026

From synaptic transmission to neural circuits: multilevel effects of stress on the hippocampus, bed nucleus of the stria terminalis, and paraventricular hypothalamic nucleus.

Hongye Zhou, Xinyi Wang, Sha Sha

Abstract readReview
In one paragraph

Review in Frontiers in systems neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hongye ZhouDepartment of Physiology, Nanjing Medical University, Nanjing, China.
Xinyi WangDepartment of Physiology, Nanjing Medical University, Nanjing, China.
Sha ShaDepartment of Physiology, Nanjing Medical University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The stress response is a non-specific adaptive physiological reaction that occurs when the organism is exposed to internal or external environmental stimuli, serving to maintain homeostatic balance. Its regulation involves highly complex neural mechanisms. The hippocampus, the bed nucleus of the stria terminalis (BNST), and the paraventricular hypothalamic nucleus (PVN) are key brain regions that play crucial roles in stress regulation. Focusing on the functional connectivity of the hippocampus-BNST-PVN neural circuit, this article systematically elucidates the multilevel effects of stress on synaptic transmission, synaptic plasticity, neural network integration, and related molecular mechanisms from microcosmic neurotransmitters to macroscopic neural circuits. These insights provide an important perspective for advancing our understanding of the neurobiological basis of stress and for developing new intervention strategies.

Indexed as

bed nucleus of the stria terminalishippocampusparaventricular hypothalamic nucleusstresssynaptic function

Identifiers

PMID42518678
PMCPMC13381638

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.