Evidence map›Paper›PMID 42518664›Full record

ArticleLancet regional health. Americas2026

Late childhood and adolescent health outcomes in preterm-born infants during 2004-2012: a population-based cohort study in British Columbia, Canada.

Sumera Aziz Ali, Ye Shen, Jeffrey N Bone, Lindsay L Richter, Sarka Lisonkova, Faith Gette, Emily Kieran, Edmond S Chan, Cherry Mammen, Carol Lam and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lancet regional health. Americas, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Sumera Aziz AliDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Ye ShenClinical Research Support Unit, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Jeffrey N BoneClinical Research Support Unit, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Lindsay L RichterDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Sarka LisonkovaDepartment of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada.
Faith GetteDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Emily KieranDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Edmond S ChanDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Cherry MammenDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Carol LamDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Ashley RobertsDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Kristopher T KangDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Dax G RumseyDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Tara McGrathDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Kevin C HarrisDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Connie L YangDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Jonathan WongDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Natalie H ChanDepartment of Pediatrics, University of California at San Francisco, San Francisco, CA, United States of America.
James LeeDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Shahrad R RassekhDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Anthony Kc ChanMcMaster Children's Hospital, McMaster University, Hamilton, ON, Canada.
Joseph Y TingDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Despite improvements in newborn care, preterm birth remains linked to long-term adverse health outcomes. This study examines health outcomes among children and adolescents (10-17 years) born preterm and surviving to age 10 years. Methods: Utilizing perinatal and health registries of British Columbia, we included individuals born between 2004 and 2012 at 22-44 weeks' gestation who survived to age 10 years, with follow-up until 2022. Health outcomes were identified via outpatient and inpatient diagnostic codes. Cox proportional hazards models estimated adjusted hazard ratios (aHRs) with 95% confidence intervals (CI). Findings: Among 297,477 individuals, 6082 (2.0%) were born at 22-33 weeks' gestational age, 21,396 (7.2%) at 34-36 weeks, and 269,999 (90.8%) were at 37-44 weeks. Individuals born at 22-33 vs. 37-44 weeks had elevated risks of growth disorders (aHR 2.12, 95% CI 1.18-3.82) and vitamin D deficiency (aHR 1.38, 95% CI 1.05-1.80). Risks for cardiac (aHR 1.50, 95% CI 1.26-1.79), renal (aHR 1.25, 95% CI 1.13-1.39), and sleep disorders (aHR 1.30, 95% CI 1.12-1.50) were higher in individuals born at 34-36 vs. 37-44 weeks GA. Risks for hypothyroidism, neurological, respiratory, puberty, and sexual development disorders increased with decreasing gestational age. Interpretation: Children and adolescents born preterm who survived to age 10 years remain at increased risk of developing adverse health outcomes, emphasizing the necessity for targeted healthcare interventions to reduce long-term morbidity. Funding: British Columbia Women's Health Research Institute (2019), Canadian Institute of Health Research (2022), and Women and Children's Health Research Institute (2021-2026).

Indexed as

AdolescenceCanadaLate childhoodLong-term health outcomesPopulation-based cohortPreterm birth

Identifiers

PMID42518664
PMCPMC13382341

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.