Evidence map›Paper›PMID 42518654›Full record

ArticleBioactive materials2026

Chitosan-based nerve guidance conduits functionalized with fibroblast-derived extracellular vesicles promote peripheral nerve regeneration via miR-143-3p delivery.

Dingding Shen, Jiahui He, Miaomei Yu, Zhenghang Cheng, Jingya Liu, Yue Zhao, Shiran Wang, Ruoyu Pei, Fei Ding, Qianru He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dingding ShenDepartment of Pathology in Medical School, Department of Neurology in Affiliated Hospital of Nantong University, Nantong University, Nantong, China.
Jiahui HeKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, China.
Miaomei YuClinical Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Zhenghang ChengKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, China.
Jingya LiuKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, China.
Yue ZhaoKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, China.
Shiran WangDepartment of Pathology in Medical School, Department of Neurology in Affiliated Hospital of Nantong University, Nantong University, Nantong, China.
Ruoyu PeiDepartment of Pathology in Medical School, Department of Neurology in Affiliated Hospital of Nantong University, Nantong University, Nantong, China.
Fei DingKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, China.
Qianru HeDepartment of Pathology in Medical School, Department of Neurology in Affiliated Hospital of Nantong University, Nantong University, Nantong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibroblasts, one of the core cellular components of peripheral nerves, play a pivotal role during peripheral nerve regeneration; however, whether extracellular vesicles (EVs) derived from peripheral nerve fibroblasts promote nerve regeneration remains unclear. In this study, we first demonstrated that EVs derived from peripheral nerve fibroblasts (fibroblasts-EVs) significantly promoted the growth and regeneration of motor and sensory neurons

Indexed as

Extracellular vesiclesFibroblastsLimk 1miR-143-3pNerve guidance conduit

Identifiers

PMID42518654
PMCPMC13382288

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.