Evidence map›Paper›PMID 42518591›Full record

Observational studyFrontiers in public health2026

Study protocol: longitudinal observational study on frailty and mental health.

Petra Mikolič Brence, Branko Bregar, Katarina Vatovec, Tjaša Bertole, Suzana Oreški, Marjeta Ferlan Istinič, Lina Berlot, Matej Vinko

Abstract readObservational Study
In one paragraph

Observational study in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Petra Mikolič BrenceCenter for Mental Health, National Institute of Public Health, Ljubljana, Slovenia.
Branko BregarCenter for Mental Health, National Institute of Public Health, Ljubljana, Slovenia.
Katarina VatovecCenter for Mental Health, National Institute of Public Health, Ljubljana, Slovenia.
Tjaša BertoleCenter for Mental Health, National Institute of Public Health, Ljubljana, Slovenia.
Suzana OreškiCenter for Mental Health, National Institute of Public Health, Ljubljana, Slovenia.
Marjeta Ferlan IstiničCenter for Mental Health, National Institute of Public Health, Ljubljana, Slovenia.
Lina BerlotCenter for Mental Health, National Institute of Public Health, Ljubljana, Slovenia.
Matej VinkoCenter for Mental Health, National Institute of Public Health, Ljubljana, Slovenia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Frailty is a dynamic condition associated with increased vulnerability to adverse health outcomes in older adults. While previous research has primarily focused on deficit-based mental health factors, such as depression and loneliness, less is known about the role of positive mental health determinants, including wellbeing, resilience and social connectedness, in the development and progression of frailty. Understanding both risk and protective factors is essential for informing public health strategies aimed at promoting healthy aging. This study aims to examine the longitudinal relationship between mental health and frailty in a nationally sampled population of adults aged 50 years and older in Slovenia. Methods and analysis: This longitudinal observational cohort study will collect data at four time points over a 2-year period (January 2026-March 2028). A stratified random sample of community-dwelling adults aged 50-84 years will be drawn from the national population registry, with 5,000 individuals invited to participate in the first wave. Frailty, mental health and a set of social, psychological, and health-related factors will be assessed. Data will be analyzed using a combination of descriptive, inferential and longitudinal statistical methods to examine associations between frailty and mental health over time. Potential explanatory factors will also be explored within the longitudinal framework, and additional analyses will assess the impact of attrition.

Indexed as

Frail ElderlyFrailtyMental HealthAgedAged, 80 and overFemaleHumansLongitudinal StudiesMaleMiddle AgedSloveniafrailtylongitudinal studymental healtholder adultspublic health

Identifiers

PMID42518591
PMCPMC13384099

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.