Evidence map›Paper›PMID 42518529›Full record

ArticleFood chemistry. Molecular sciences2026

Structure-function insights into the digestive fate of angiotensin-converting enzyme-inhibitory peptides from microwave-treated corn gluten meal.

Ali Hamzeh, Wasana Wongngam, Sittiruk Roytrakul, Sasitorn Aueviriyavit, Ratjika Wongwanakul, Fu Tian, Jirawat Yongsawatdigul, Rotimi E Aluko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food chemistry. Molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ali HamzehInstitute of Research and Development, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Wasana WongngamDepartment of Agro-Industry, Faculty of Agricultural and Technology, Rajamangala University of Technology Isan SURIN Campus, Surin 32000, Thailand.
Sittiruk RoytrakulNational Center for Genetic Engineering and biotechnology, Pathum Thani 12120, Thailand.
Sasitorn AueviriyavitNational Nanotechnology Center, National Science and Technology Development Agency, 111 Thailand Science Park, Pathum Thani 12120, Thailand.
Ratjika WongwanakulNational Nanotechnology Center, National Science and Technology Development Agency, 111 Thailand Science Park, Pathum Thani 12120, Thailand.
Fu TianCollege of Food and Pharmaceutical Engineering, Guizhou Institute of Technology, Guiyang 550000, China.
Jirawat YongsawatdigulSchool of Food Technology, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Rotimi E AlukoDepartment of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corn gluten meal (CGM) is an underutilized byproduct with rigid structure, which limits efficient peptide release during enzymatic hydrolysis. While microwave pretreatment can disrupt the rigid CGM matrix and enhance peptide release, this study investigated how downstream gastrointestinal modification and transport behavior ultimately influence the functional fate of the enzymatically liberated peptide sequences. Enzymatic hydrolysis of microwave-pretreated CGM led to a 3.3-fold increase in peptide yield while maintaining angiotensin-converting enzyme (ACE)-inhibitory activity at a level comparable to that of the untreated CGM hydrolysate. From this digest, the purified peptide DVPSADAPAAAV (DV-12) exhibited potent

Indexed as

Bioactive peptidesCaco-2 permeabilityGastrointestinal digestionMolecular dynamics

Identifiers

PMID42518529
PMCPMC13382275

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.