ArticleCancer management and research2026
Clonal Seborrheic Keratosis with Adjacent Bowen's Disease in a Non-Sun-Exposed Patient: Collision or Transformation?
Article in Cancer management and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
We report a case of clonal seborrheic keratosis (CPSK) adjacent to Bowen's disease (BD) in a 29‑year‑old male with no history of chronic sun exposure. The lesion presented as a brown, flat papule on the right side of the back. Histopathologically, the CPSK component featured well‑demarcated intraepidermal nests of basaloid keratinocytes, consistent with the Borst‑Jadassohn phenomenon. Adjacent areas showed full‑thickness epidermal atypia, nuclear pleomorphism, and numerous mitotic figures, including atypical forms, characteristic of BD. No clear transitional zone was identified between the two components. These findings align most closely with a collision tumor-coincidental coexistence of two independent neoplasms-rather than true malignant transformation of CPSK into BD. This case underscores the need for careful histologic evaluation to distinguish collision from transformation, particularly in the absence of chronic ultraviolet exposure.
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