ArticleACS omega2026
Photochemically Engineered, DNA-Functionalized AgCl@AuAg Nanoprobes for Colorimetric Detection of Target DNA via In Situ Catalytic Amplification.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Colorimetric DNA detection is attractive for point-of-care testing, yet sensitivity often remains insufficient for clinically relevant applications/targets. We report a signal-amplification strategy that uses DNA-functionalized AgCl@AuAg nanoparticles (DNA-AgCl@AuAgNPs) as chemically transformable catalytic nanoprobes. To overcome the inherent challenge of functionalizing ionic AgCl surfaces, we employed a photochemical reduction method to decorate cubic AgCl nanoparticles (AgClNPs) with Au/Ag metallic domains (AgCl@AuAgNPs). These metallic "bumps" serve as stable anchoring sites for thiol-modified probe DNA, enabling sequence-specific target recognition. In a magnetic sandwich assay, target DNA mediates sandwich hybridization between DNA-AgCl@AuAgNPs and DNA-modified magnetic microparticles (DNA-MMPs). After selective isolation of target-bound complexes using an external magnetic field, the captured nanoprobes undergo rapid in situ chemical transformation triggered by NaBH
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