ArticleACS omega2026
Enhanced Genetically Variant Peptide Profiling from Human Hair Using Multiple Enzymes.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetically variant peptides (GVPs) derived from human hair proteins have been studied as evidence for forensic human identification. For this purpose, trypsin is generally routinely used as the protease for peptide generation. We hypothesized that the use of different proteases can expand sequence coverage in the hair proteome and, therefore, increase the chance of a variant peptide being identified and confirm the findings from tryptic digests. Since keratins and keratin-associated proteins are the main components of the hair proteome, we examined several alternative enzymes other than trypsin, including keratinase, chymotrypsin, and Glu-C. We found that the use of multiple enzymes led to enhanced GVP profiling and, therefore, an increase in the confidence of GVP identification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.