Evidence map›Paper›PMID 42518375›Full record

ArticleThe World Allergy Organization journal2026

HMGB1 impairs nasal epithelial barrier via regulating autophagy in the pathogenesis of allergic rhinitis.

Yuhao Fan, Miaomiao Xu, Liya Ren, Congcong Lu, Yilin Li, Fuhai Chen, Zhiqi Ma, Yong Li, Xiaolin Cao, Jing Li

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In one paragraph

Article in The World Allergy Organization journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuhao FanDepartment of Otolaryngology-Head and Neck Surgery, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, 310006, Hangzhou, Zhejiang Province, China.
Miaomiao XuThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, 310006, Hangzhou, Zhejiang Province, China.
Liya RenThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, 310006, Hangzhou, Zhejiang Province, China.
Congcong LuThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, 310006, Hangzhou, Zhejiang Province, China.
Yilin LiDepartment of Otolaryngology-Head and Neck Surgery, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, 310006, Hangzhou, Zhejiang Province, China.
Fuhai ChenDepartment of Otolaryngology-Head and Neck Surgery, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, 310006, Hangzhou, Zhejiang Province, China.
Zhiqi MaDepartment of Otolaryngology-Head and Neck Surgery, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, 310006, Hangzhou, Zhejiang Province, China.
Yong LiDepartment of Otolaryngology-Head and Neck Surgery, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, 310006, Hangzhou, Zhejiang Province, China.
Xiaolin CaoDepartment of Otolaryngology-Head and Neck Surgery, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, 310006, Hangzhou, Zhejiang Province, China.
Jing LiDepartment of Otolaryngology-Head and Neck Surgery, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, 310006, Hangzhou, Zhejiang Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Numerous studies indicate that the epithelial barrier was disrupted in allergic rhinitis (AR). High-mobility group box 1(HMGB1) plays a significant role in activating inflammation. We aimed to explore whether HMGB1 could impair the epithelial barrier in AR and investigate its underlying mechanism. Methods: Nasal secretions and nasal specimens were collected. Expression of HMGB1 and tight junction (TJ) proteins were measured by RT-qPCR, western blotting and immunofluorescence in control subjects and AR patients. Hematoxylin and eosin staining was used for histological examination. Cell proliferation and migration were assessed by CCK-8 and wound healing assays. Primary human nasal epithelial cells (pHNECs) were processed by air-liquid interface (ALI) technique and treated with recombinant HMGB1 protein. Lentivirus mRFP-sGFP-LC3 was transfected to detect autophagy flux. An OVA-induced mouse model was used to investigate the role of HMGB1 Results: The level of HMGB1 was significantly elevated in the nasal secretions of AR patients (P < 0.001) and positively correlated with symptom severity (VAS scores) (r = 0.4863, P = 0.0064). Both Conclusion: HMGB1 was highly expressed in AR patients and correlated with disease severity. It impaired the integrity of the epithelial barrier by inhibiting the degradation of autophagosomes. Both GLY and EP treatments restored impaired epithelial barrier by inhibiting HMGB1.

Indexed as

Allergic rhinitisAutophagyEpithelial barrierHMGB1

Identifiers

PMID42518375
PMCPMC13382246

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.