Evidence map›Paper›PMID 42518330›Full record

ArticleNeuroimage. Reports2026

Task-evoked network connectivity and pain regulation success in chronic low back pain.

Steven R Anderson, Gadi Gilam, Christine Law, Kenneth A Weber, Philippe R Goldin, Tor D Wager, Jiang-Ti Kong, Beth D Darnall, James J Gross, Sean C Mackey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroimage. Reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Steven R AndersonDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, USA.
Gadi GilamThe Institute of Biomedical and Oral Research, Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Christine LawDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, USA.
Kenneth A WeberDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, USA.
Philippe R GoldinBetty Irene Moore School of Nursing, University of California, Davis, USA.
Tor D WagerDepartment of Psychological and Brain Sciences, Dartmouth College, Hanover, USA.
Jiang-Ti KongDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, USA.
Beth D DarnallDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, USA.
James J GrossStanford University, Department of Psychology, Stanford, USA.
Sean C MackeyDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resting-state functional connectivity (rsFC) has shown widespread changes in intrinsic functional brain networks in individuals with chronic low back pain (CLBP). However, less is known about rsFC between task-evoked brain networks (i.e., networks formed by regions that are activated to tasks) implicated in cognitive reappraisal and attention regulation in this population. This cross-sectional study analyzed resting-state fMRI and behavioral data from a separate pain regulation task in 184 individuals with CLBP to investigate whether rsFC among ROIs defined from task-based meta-analyses of cognitive reappraisal and attention regulation networks was associated with pain regulation success. We hypothesized that increased rsFC within and between task-based networks would be associated with greater pain regulation success, and that trait cognitive reappraisal and mindfulness would mediate these relationships. Results indicated that increased rsFC between ROIs in the task-based cognitive reappraisal network, including the left ventrolateral prefrontal cortex (vlPFC) and left middle temporal gyrus (MTG), was associated with reduced pain regulation success using either cognitive reappraisal or attention regulation. Conversely, increased rsFC between ROIs in the task-based cognitive reappraisal network left vlFPC and attention regulation network right middle frontal gyrus (MFG) was associated with increased pain regulation success using attention regulation. Examining the relationship between rsFC and self-reported measures of pain, cognition, and emotion, we found that increased rsFC between the task-based cognitive reappraisal network left MTG and attention regulation network right inferior frontal gyrus (IFG) was associated with increased self-reported cognitive distortions. In contrast, increased rsFC between the task-based attention regulation network bilateral vlPFC and left posterior cingulate cortex (PCC) was associated with more habitual use of cognitive reappraisal, lower pain catastrophizing, and lower depression. In a formal mediation analysis, neither trait cognitive reappraisal nor trait mindfulness mediated the relationship between rsFC and pain regulation success. Together, our findings suggest that rsFC between brain regions in task-based cognitive reappraisal and attention regulation networks is related to behavioral outcomes in a separate evoked pain regulation task and may underlie cognition and emotion regulation success in individuals with CLBP.

Indexed as

Attention regulationChronic low back painCognitive reappraisalPain regulationResting-state fMRI

Identifiers

PMID42518330
PMCPMC13382298

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.