Evidence map›Paper›PMID 42518326›Full record

ArticleJournal of the American Statistical Association2026

Theory for Identification and Inference with Synthetic Controls: A Proximal Causal Inference Framework.

Xu Shi, Kendrick Qijun Li, Myeonghun Yu, Wang Miao, Arun Kumar Kuchibhotla, Mengtong Hu, Eric Tchetgen Tchetgen

Abstract read
In one paragraph

Article in Journal of the American Statistical Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Imperfect Synthetic Controls.Journal of applied econometrics (Chichester, England) · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. INTRODUCING PROXIMAL CAUSAL INFERENCE FOR EPIDEMIOLOGISTS.American journal of epidemiology · 2023
    Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xu ShiDepartment of Biostatistics, University of Michigan, Ann Arbor, MI.ORCID 0000-0001-8566-9552
Kendrick Qijun LiDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0003-3040-7250
Myeonghun YuDepartment of Biostatistics, University of Michigan, Ann Arbor, MI.
Wang MiaoDepartment of Probability and Statistics, Peking University, Beijing, China.
Arun Kumar KuchibhotlaDepartment of Statistics and Data Science, Carnegie Mellon University, Pittsburgh, PA.
Mengtong HuDepartment of Biostatistics, University of Michigan, Ann Arbor, MI.
Eric Tchetgen TchetgenStatistics Department, The Wharton School, University of Pennsylvania, Philadelphia, PA.

Funding

Accounting for Hidden Bias in Vaccine Studies: A Negative Control FrameworkR01GM139926 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHI, XU, TCHETGEN TCHETGEN, ERIC JOEL · 2021 to 2024
$1.5M
NIGMS NIH HHS R01 GM139926
6 · The paper itself

Abstract

Synthetic control (SC) methods are commonly used to estimate the treatment effect on a single treated unit in panel data settings. An SC is a weighted average of control units built to match the treated unit, with weights typically estimated by regressing pretreatment outcomes and measured covariates of the treated unit to those of the control units. However, the classical SC method was primarily proposed for empirical settings where a good pretreatment fit is attainable. In this article, we introduce a proximal causal inference framework to formalize identification and inference for both the SC and ultimately the treatment effect on the treated, based on the observation that control units not contributing to the construction of an SC can be repurposed as proxies of latent confounders, thus, extending the applicability of SC methods to cases where the pretreatment fit is poor even with many pretreatment periods. We show that several existing uncertainty quantification methods of treatment effect for the classical SC methods can be adapted to the proximal inference approach. The proposed framework can accommodate nonlinear models, which allows for binary and count outcomes both of which remain understudied in the SC literature. We illustrate with comprehensive simulation studies and an application to the evaluation of the 1990 German Reunification. Supplementary materials for this article are available online, including a standardized description of the materials available for reproducing the work.

Indexed as

Panel dataProximal causal inferenceSynthetic controlTime series

Identifiers

PMID42518326
PMCPMC13384440

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.