Evidence map›Paper›PMID 42518274›Full record

ArticleThe Journal of clinical investigation2026

The CRAC channel inhibitor Auxora reprograms pathogenic alveolar macrophage-T cell circuits in viral pneumonia.

S Marina Casalino-Matsuda, Vijeeth Guggilla, Catherine A Gao, Kaitlyn E DeMeulenaere, Luisa Cusick, Samuel W Fenske, Zhan Yu, Ziyan Lu, Suchitra Swaminathan, Rogan A Grant and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

S Marina Casalino-MatsudaDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Vijeeth GuggillaHealth Sciences Integrated Program, Health and Biomedical Informatics Track, and.
Catherine A GaoDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Kaitlyn E DeMeulenaereDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Luisa CusickDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Samuel W FenskeDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Zhan YuDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Ziyan LuDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Suchitra SwaminathanDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Rogan A GrantDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Maxwell J SchleckDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Murali PrakriyaDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Sudarshan HebbarCalciMedica Inc., La Jolla, California, USA.
Kenneth StaudermanCalciMedica Inc., La Jolla, California, USA.
Helen K DonnellyDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Chiagozie I PickensDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Luisa Morales-NebredaDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Richard G WunderinkDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Alexander V MisharinDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Benjamin D SingerDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
G R Scott BudingerDivision of Pulmonary and Critical Care Medicine, Department of Medicine.

Funding

Role of LUBAC and Na K-ATPase in Acute Lung InjuryP01HL071643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2003 to 2019
$30.8M
Technology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RICHARD G WUNDERINK · 2018 to 2026
$24.7M
The Cell Phenotyping and Mouse CoreP01HL154998 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE · 2021 to 2026
$18.9M
Synergistic roles of lung autoantibodies, donor nonclassical monocytes and recipient classical monocytes in mediating primary graft dysfunctionP01HL169188 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat · 2024 to 2026
$11.1M
The Neu-Lung Consortium: Neutrophilic Mechanisms of Inflammation, Injury, and Repair in Lung and Airways DiseasesU19AI181102 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Max A Seibold · 2024 to 2026
$9.3M
Role of spleen educated monocytes in mediating ischemia-reperfusion injury followinglung transplant surgeryR01HL147575 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat, GR Scott Budinger · 2019 to 2026
$5.5M
Pathogenesis of lung injury mediated by lung-restricted antibodiesR01HL147290 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat, GR Scott Budinger · 2019 to 2026
$5.2M
Donor nonclassical monocytes mediate primary graft dysfunction and remote organ injury following lung transplant surgeryR01HL145478 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat, GR Scott Budinger · 2019 to 2026
$4.8M
Mechanisms of regulatory T cell-mediated recovery from severe viral pneumoniaR01HL149883 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2020 to 2026
$4.1M
Lung transplant injury drives chronic lung allograft dysfunction via recruitment ofmonocyte-derived alveolar macrophagesR01HL153312 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MISHARIN, ALEXANDER · 2020 to 2023
$2.9M
Targeting abnormal alveolar immune activation and failed epithelial repair in COVID-19R01HL158139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BUDINGER, GR SCOTT, MISHARIN, ALEXANDER · 2022 to 2025
$2.9M
Complementary pathways of necroptosis in recipient and donor lung tissue that drive primary lung allograft dysfunctionR01HL173940 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat, GR Scott Budinger · 2024 to 2026
$2.4M
NHLBI NIH HHS K23 HL169815NHLBI NIH HHS P01 HL071643NHLBI NIH HHS P01 HL154998NHLBI NIH HHS P01 HL169188NHLBI NIH HHS R01 HL145478NHLBI NIH HHS R01 HL147290NHLBI NIH HHS R01 HL147575NHLBI NIH HHS R01 HL149883NHLBI NIH HHS R01 HL153122NHLBI NIH HHS R01 HL153312NHLBI NIH HHS R01 HL154686NHLBI NIH HHS R01 HL158139NHLBI NIH HHS R01 HL173940NIAID NIH HHS U19 AI135964NIAID NIH HHS U19 AI181102
6 · The paper itself

Abstract

The CRAC channel inhibitor Auxora Reprograms Pathogenic Alveolar Macrophage-T Cell Circuits in Viral Pneumonia.

Indexed as

Calcium Channel BlockersCalcium ChannelsMacrophages, AlveolarPneumonia, ViralT-LymphocytesAnimalsBenzamidesHumansMicePyrazinesBenzamidesCalcium Channel BlockersCalcium ChannelsPyrazineszegocractinCalcium channelsImmunologyInfectious diseaseMacrophagesPulmonologyT cells

Identifiers

PMID42518274
PMCPMC13574160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.