Evidence map›Paper›PMID 42518174›Full record

ArticleClinical implant dentistry and related research2026

Hybrid Funnel Technique Reduces Marginal Bone Loss Versus Conventional Drilling: A 3-Year, Prospective, Non-randomized, Controlled Clinical Trial.

Luigi Canullo, Yaniv Mayer, Federica Mattalia, Iole D'Urso, Filiberto Mastrangelo, Vito Carlo Alberto Caponio

Abstract readControlled Clinical TrialComparative Study
In one paragraph

Article in Clinical implant dentistry and related research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Luigi CanulloDepartment of Prosthodontic, University of Saint Camillus, Rome, Italy.ORCID https://orcid.org/0000-0001-9875-2929
Yaniv MayerRuth and Bruce Rappaport Faculty of Medicine at the Technion, Haifa, Israel.ORCID https://orcid.org/0000-0001-5500-7961
Federica MattaliaDepartment of Surgical Sciences and Integrated Diagnostics, University of Genova, Genoa, Italy.ORCID https://orcid.org/0009-0001-1562-3660
Iole D'UrsoDepartment of Surgical Sciences and Integrated Diagnostics, University of Genova, Genoa, Italy.ORCID https://orcid.org/0009-0005-7171-3491
Filiberto MastrangeloDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.ORCID https://orcid.org/0000-0002-3746-5675
Vito Carlo Alberto CaponioDepartment of Life Sciences, Health and Health Professions, Link Campus University, Rome, Italy.ORCID https://orcid.org/0000-0001-5080-5921

Funding

Alpha-Bio Tec Ltd.
6 · The paper itself

Abstract

purposeThis study aimed to compare marginal bone loss (MBL) associated with Hybrid Funnel Technique (HFT) and conventional drill osteotomy for implant site preparation when bioactive implants are used, testing the null hypothesis that no significant differences occur at 1- and 3 years. MATERIALS AND

methodsThis prospective non-randomized controlled clinical trial included patients undergoing implant rehabilitation with bioactive-surface implants. Implants were placed using either conventional subtractive drilling (control group) or HFT (test group), which combines selective cortical preparation with medullary osteocompaction. The primary outcome was radiographic MBL at 3-year follow-up. Secondary outcomes included bleeding on probing (BoP) and plaque index (PI). Statistical analyses were performed at implant level, and linear mixed-effects models were used to account for clustering within patients and adjust for potential confounders.

resultsA total of 87 implants in 43 patients were analyzed (42 control, 45 HFT). At 1-year follow-up, the test group reported significantly lower MBL (0.33 ± 0.43 mm vs. mean = 0.78 ± 0.82 mm; Mann-Whitney p-value = 0.006). At 3 years, MBL was significantly higher in the conventional site preparation group compared with the HFT group (1.34 ± 0.79 mm vs. 0.46 ± 0.69 mm; p < 0.001). In multivariate mixed-effects analysis, the implant site preparation technique was the only variable independently associated with MBL at 3 years (β = -1.10 mm, 95% CI = -1.675 to -0.527, p < 0.001), while insertion torque and other baseline variables showed no significant association. In addition, the HFT group demonstrated significantly lower BoP and PI scores, indicating more favorable peri-implant soft tissue conditions.

conclusionsDespite the use of identical bioactive-surface implants, implant site preparation technique significantly influenced peri-implant bone remodeling. HFT demonstrated superior preservation of marginal bone over 3 years, suggesting that reduction of cortical compression during osteotomy provides a biological advantage. Implant site preparation remains a key determinant of long-term peri-implant bone stability.

Indexed as

Alveolar Bone LossDental Implantation, EndosseousOsteotomyDental ImplantsFemaleHumansMaleMiddle AgedProspective StudiesDental Implantsbioactive implant surfacedental implantshybrid funnel techniqueimplant site preparationmarginal bone lossosseointegrationperi‐implant bone

Identifiers

PMID42518174
PMCPMC13411644

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.