SynthesisBrain and behavior2026
Intravenous Thrombolysis Combined With Endovascular Treatment Versus Endovascular Treatment Alone in Acute Ischemic Stroke due to Tandem Lesions: A Systematic Review and Meta-Analysis.
Synthesis in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveFor patients suffering from acute ischemic stroke (AIS) brought on by tandem lesions (TL), to compare the safety and efficacy of intravenous thrombolysis (IVT) in conjunction with endovascular therapy (EVT) to EVT alone.
methodsRelevant studies published up until October 20, 2024, were found by a systematic assessment of the literature from the PubMed, Embase, and Cochrane databases. Results such as the 90-day modified Rankin Scale (mRS) score, effective recanalization, symptomatic intracerebral hemorrhage (sICH), and 90-day mortality were the main focus of the comparison between IVT plus EVT and EVT alone in patients with TL.
resultsA total of 1756 patients from nine studies were included in the final analysis; 976 of these patients were categorized as IVT + EVT group patients, and 780 as EVT alone group patients. The IVT plus EVT group was associated with a higher rate of successful recanalization (modified Thrombolysis in Cerebral Infarction score [mTICI] ≥ 2b/3) (RR = 1.11; 95% CI, 1.04-1.18; p < 0.05; I
conclusionIVT + EVT, as opposed to EVT alone, may be correlated with superior functional results at 90 days in AIS patients with TL.
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