Evidence map›Paper›PMID 42518157›Full record

ArticleJournal of racial and ethnic health disparities2026

Allostatic Load, Neighborhood Disadvantage, and Birth Outcomes.

Cynthia Wynn, Jiashu Zhao, Michael Petriello, Gwendolyn S Norman, Nicholas Weil, Sarah S Comstock, Kimberly S McKee

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of racial and ethnic health disparities, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cynthia WynnDepartment of Family Medicine, University of Michigan, Ann Arbor, MI, USA. clwynn@med.umich.edu.ORCID http://orcid.org/0009-0006-4352-4738
Jiashu ZhaoInstitute for Social Research Population Studies Center, University of Michigan, Ann Arbor, MI, USA.
Michael PetrielloInstitute of Environmental Health Sciences, Department of Pharmacology, Wayne State University, Detroit, MI, USA.ORCID http://orcid.org/0000-0002-5583-8092
Gwendolyn S NormanDepartment of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA.ORCID http://orcid.org/0000-0003-0483-286X
Nicholas WeilRS&GIS, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0009-0009-2285-3753
Sarah S ComstockDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0000-0003-3107-7652
Kimberly S McKeeDepartment of Family Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-2905-5000

Funding

Prenatal Exposures and Child Health Outcomes: A Statewide StudyUG3OD023285 · OD · MICHIGAN STATE UNIVERSITY · PI BARONE, CHARLES JAMES, ELLIOTT, MICHAEL R. · 2016 to 2024
$12.9M
Translational Research Support CoreP30ES036084 · NIEHS · WAYNE STATE UNIVERSITY · PI Melissa A Runge-Morris · 2024 to 2026
$5.2M
Child Health Advances from Research with Mothers (CHARM) small grant program Child Health Advances from Research with Mothers (CHARM) small grant programEnvironmental Influences on Child Health Outcomes (ECHO) Program, Office of The Director, National Institutes of Health UH3OD023285Michigan Health Endowment Fund G-1608-140432Michigan Health Endowment Fund R-1605-140007NIEHS NIH HHS P30 ES036084NIH Office of the Director UG3OD023285Population Dynamics and Health Program, National Institute of Child Health and Human Development (NICHD) Center Grant P2CHD041028University of Michigan, Office of the Vice President of Research Environmental and Biosocial Effects of Structural Racism on Birth Outcomes U084834-427604
6 · The paper itself

Abstract

objectivesWe examined if the Index of Concentration at the Extremes, a measure of neighborhood disadvantage, was associated with preterm birth (PTB) and assessed mediation by allostatic load (AL).

methodsWe examined a subset of the Michigan Archive for Research on Child Health, a prospective ongoing cohort that began in 2016, with select biomarkers and prenatal records. We operationalized AL from the sum of eight parameters drawn from inflammatory biomarkers and prenatal records, which we dichotomized as ≥ 4 (High) or < 4 (Low). We tested for mediation of AL using Generalized Estimating Equations models clustered by zip code.

resultsOf the n = 392, 46% were Black, 16% of which delivered preterm. Black pregnant people had 1.21 times higher PTB odds if they lived in a more privileged county compared to those who did not (OR = 1.21, 95% CI = 0.54, 2.73) while non-Blacks had 36% lower odds (OR = 0.64, 95% CI = 0.22, 1.85), but neither were statistically significant. Living in a more privileged county was significantly associated with 70% lower odds of high AL (OR = 0.30, 95% CI = 0.13, 0.68). Both groups had higher although not statistically significant odds of PTB if they had high AL scores (Black: OR = 1.22, 95% CI = 0.42, 3.57; Non-Black: OR = 3.24, 95% CI = 0.32, 33.11).

conclusionAlthough we observed trends in neighborhood disadvantage on PTB, the effects were not significant. Black pregnant people had a higher AL, but there was no evidence that AL mediated the association.

Indexed as

Allostatic loadBirth outcomesHealth disparitiesIndex of Concentration at the ExtremesNeighborhood disadvantagePreterm birth

Identifiers

PMID42518157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.