ArticleAdvances in therapy2026
Factors Associated with Favorable One-Year Outcomes After PreserFlo MicroShunt Implantation: Insights from Anterior Segment Optical Coherence Tomography.
Article in Advances in therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionThis study aimed to identify factors associated with favorable 1-year surgical outcomes after PreserFlo MicroShunt (PMS) implantation, with a particular focus on baseline ocular anatomy and postoperative filtration patterns assessed by anterior segment optical coherence tomography (AS-OCT).
methodsThis cohort study included individuals with primary open-angle or exfoliation glaucoma who underwent PMS implantation. AS-OCT was performed 1 month postoperatively. Surgical success was defined by hypertensive thresholds of 12 mmHg (A), 15 mmHg (B), and 18 mmHg (C), with an intraocular pressure (IOP) reduction of ≥ 20% from baseline. Each criterion had a hypotensive limit of 6 mmHg. Multivariable Cox proportional hazards models were used to evaluate factors associated with favorable outcomes, considering both hypertensive and hypotensive failure limits.
resultsEighty-eight eyes were analyzed. Median IOP decreased from 19 mmHg (interquartile range: 16-23.8) to 10 mmHg (8-13) at 12 months (p < 0.001). Qualified success rates at 12 months were 56.8% for criterion A, 70.5% for criterion B, and 73.9% for criterion C. Filtration toward the corneal limbus on AS-OCT was associated with a lower risk of hypertensive failure across all criteria (HR, 0.28-0.57; p = 0.008-0.031). Longer axial length was significant for criteria B and C (HR, 0.70 and 0.77; p = 0.002 and 0.008). Older age and exfoliation glaucoma were risk factors for hypotensive failure (HR, 1.05 and 3.75; p = 0.01 and 0.006).
conclusionBoth baseline ocular anatomy, represented by axial length, and filtration toward the corneal limbus on AS-OCT were independently associated with favorable 1-year outcomes following PMS implantation. Integrating preoperative anatomical assessment with early postoperative imaging findings may help clinicians better understand individual surgical responses.
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