Evidence map›Paper›PMID 42518066›Full record

ArticleBulletin of experimental biology and medicine2026

The "Double-Hit" Model in Experimental Parkinsonism: Effects of Combined Exposure to Lactacystin and LPS.

A V Stavrovskaya, A A Gerasimov, D N Voronkov, A S Romanenko, A S Olshanskiy, A K Pavlova, S N Illarioshkin

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Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

A V StavrovskayaRussian Center of Neurology and Neurosciences, Moscow, Russia. alla_stav@mail.ru.
A A GerasimovRussian Center of Neurology and Neurosciences, Moscow, Russia.
D N VoronkovRussian Center of Neurology and Neurosciences, Moscow, Russia.
A S RomanenkoRussian Center of Neurology and Neurosciences, Moscow, Russia.
A S OlshanskiyRussian Center of Neurology and Neurosciences, Moscow, Russia.
A K PavlovaRussian Center of Neurology and Neurosciences, Moscow, Russia.
S N IllarioshkinRussian Center of Neurology and Neurosciences, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to investigate a "double-hit" model of Parkinson's disease, implying intranigral administration of lactacystin and intraperitoneal injection of LPS. The model group rats exhibited significant deterioration in several parameters of the motor function (p ⩽ 0.04) and emotional impairment (p ⩽ 0.04) compared to the control. Morphological signs of neurodegeneration (p ⩽ 0.001) and microglial activation (p ⩽ 0.02) were observed in the substantia nigra. These findings support the utility of this "double-hit" model for elucidating the mechanisms underlying parkinsonism and for preclinical testing of candidate therapeutics.

Indexed as

AcetylcysteineLipopolysaccharidesParkinsonian DisordersAnimalsDisease Models, AnimalMaleMicrogliaParkinson DiseaseRatsSubstantia NigraAcetylcysteinelactacystinLipopolysaccharides“double-hit”lactacystinlipopolysaccharideneuroinflammationParkinson’s disease

Identifiers

PMID42518066

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.