Evidence map›Paper›PMID 42518033›Full record

ArticleJournal of natural medicines2026

β-glucuronidase inhibitors isolated from the fruit of Forsythia suspensa (Thunb.) Vahl.

Shogo Nishikawa, Ryuya Takada, Yusuke Shimomoto, Sara Morishita, Yoshiaki Manse, Tomoe Ohta, Tatsusada Yoshida, Takahiro Matsumoto, Toshio Morikawa

Abstract read
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In one paragraph

Article in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shogo NishikawaPharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan.
Ryuya TakadaPharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan.
Yusuke ShimomotoPharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan.
Sara MorishitaPharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan.
Yoshiaki MansePharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan.
Tomoe OhtaKyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
Tatsusada YoshidaFaculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch Machi, Sasebo, Nagasaki, 859-3298, Japan.
Takahiro MatsumotoKyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
Toshio MorikawaPharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan. morikawa@kindai.ac.jp.ORCID http://orcid.org/0000-0003-2794-5365

Funding

Japan Science and Technology Agency JPMJSP2182Japan Society for the Promotion of Science 22K06688
6 · The paper itself

Abstract

A methanol extract from the fruit of Forsythia suspensa (Thunb.) Vahl (Oleaceae), which is used as the crude drug Forsythiae Fructus (Forsythia Fruit; "Rengyo" in Japanese) and is listed in the Japanese Pharmacopoeia XIX, exerted enzymatic β-glucuronidase inhibitory activity. From the extract, we isolated a new diterpene rengyonoic acid (1) along with 19 known compounds including two diterpene (2 and 3), three triterpenes (4-6), seven lignans (7-13), two flavonoids (14 and 15), four phenylethanoids (16-19), and an aromatic compound (20). The structure of the new compound (1), including its absolute stereochemistry, was determined based on chemical and physicochemical evidence derived from NMR and MS spectrometry analysis as well as by comparing experimental and predicted ECD data. Among the isolates, 1 (IC

Indexed as

Enzyme InhibitorsForsythiaFruitGlucuronidaseGlycoproteinsPlant ExtractsDiterpenesLignansMolecular Structurebeta-glucuronidase inhibitorDiterpenesEnzyme InhibitorsGlucuronidaseGlycoproteinsLignansPlant ExtractsDiterpeneForsythia suspensaOleaceaeRengyonoic acidβ-Glucuronidase inhibitory activity

Identifiers

PMID42518033
PMCPMC13547174

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.