Evidence map›Paper›PMID 42518023›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2026

Impact of catheter ablation in asymptomatic patients with pre-excitation syndrome - real world evidence.

Maximilian Moersdorf, Christian Massad, Mohammad Montaser Atasi, Yara Menassa, Han Feng, Michel Abou-Khalil, Alex El Darzi, Carlo El Khoury, Qussay Marashly, Rodolfo Montiel and 4 more

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Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maximilian MoersdorfTulane Research Innovation for Arrhythmia Discovery, New Orleans, LA, USA.
Christian MassadTulane Research Innovation for Arrhythmia Discovery, New Orleans, LA, USA.
Mohammad Montaser AtasiTulane Research Innovation for Arrhythmia Discovery, New Orleans, LA, USA.
Yara MenassaTulane Research Innovation for Arrhythmia Discovery, New Orleans, LA, USA.
Han FengTulane Research Innovation for Arrhythmia Discovery, New Orleans, LA, USA.
Michel Abou-KhalilTulane Research Innovation for Arrhythmia Discovery, New Orleans, LA, USA.
Alex El DarziTulane Research Innovation for Arrhythmia Discovery, New Orleans, LA, USA.
Carlo El KhouryTulane Research Innovation for Arrhythmia Discovery, New Orleans, LA, USA.
Qussay MarashlyTulane Research Innovation for Arrhythmia Discovery, New Orleans, LA, USA.
Rodolfo MontielTulane Research Innovation for Arrhythmia Discovery, New Orleans, LA, USA.
Philipp SommerDepartment of Electrophysiology, Heart- and Diabetescenter NRW, Ruhr University Bochum, Medical School OWL (University Bielefeld), Bad Oeynhausen, Germany.
Amitabh C PandeyTulane Research Innovation for Arrhythmia Discovery, New Orleans, LA, USA.
Christian SohnsDepartment of Electrophysiology, Heart- and Diabetescenter NRW, Ruhr University Bochum, Medical School OWL (University Bielefeld), Bad Oeynhausen, Germany.
Nassir MarroucheTulane Research Innovation for Arrhythmia Discovery, New Orleans, LA, USA. nmarrouche@tulane.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPre-excitation syndromes such as Wolff-Parkinson-White increase risks of tachyarrhythmias and sudden cardiac death. While symptomatic patients undergo ablation, optimal management of asymptomatic individuals remains debated. This study aims to evaluate long-term outcomes of catheter ablation versus conservative management in asymptomatic patients utilizing real-world data.

methodsIn this observational cohort study using the U.S. Collaborative Network in TriNetX, patients ≥ 12 to 50 years with asymptomatic pre-excitation between September 1, 2010 and October 1, 2024 were identified. After 1:1 propensity score matching, 5,852 patients were included. The primary endpoint was all-cause mortality. Secondary endpoints included hospitalization, syncope, new onset of heart failure (HF), ventricular tachycardia/fibrillation (VT/VF), atrial fibrillation (AF) and antiarrhythmic drug (AAD) use up to 10 years of follow-up. Outcomes were compared between patients undergoing ablation versus those receiving medical therapy (GDMT).

resultsOver a mean follow-up of 1133 ± 1166 days, ablation was associated with reduced risks of the all-cause mortality (hazard ratio (HR) 0.25, 95%CI:0.13-0.48, p < 0.001), HF onset (HR 0.48, 95%CI:0.26-0.85, p = 0.011) and hospitalization rates (HR 0.47, 95%CI:0.37-0.60, p < 0.001). No significant differences were observed for new onset of VT/VF (HR 0.85, 95%CI:0.51-1.43, p = 0.534), AF (HR 1.61, 95%CI:1.00-2.62, p = 0.051) and syncope (HR 1.50, 95%CI:0.78-2.91, p = 0.224).

conclusionIn asymptomatic patients with pre-excitation, catheter ablation was associated with a reduced mortality, fewer hospitalizations, and HF onset. These findings support considering ablation as a proactive strategy in selected asymptomatic individuals.

Indexed as

All-cause mortalityCatheter ablationHeart failurePre-excitation syndrome

Identifiers

PMID42518023

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.