ArticleHistochemistry and cell biology2026
Amifostine alleviates ionizing radiation-induced small intestinal motility dysfunction in mice by remodeling the structure of the enteric nervous system.
Article in Histochemistry and cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Radiation-induced intestinal injury is characterized by structural and functional impairment of intestinal tissues following exposure to ionizing radiation, and homeostasis of the enteric nervous system is essential for preserving normal gastrointestinal physiological function. While amifostine confers radioprotection primarily through free radical scavenging and modulation of the intestinal microbiota, its regulatory effects on the enteric nervous system remain unexplored. In this study, a mouse model of radiation-induced intestinal injury was established by targeted abdominal irradiation with
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