Evidence map›Paper›PMID 42518006›Full record

ReviewCEN case reports2026

Tumor-to-tumor metastasis of breast carcinoma to clear cell renal cell carcinoma: a rare case with a review of the literature.

Nobuyuki Nakajima, Hiroshi Kajiwara, Kenta Okutsu, Toshiki Sakemura, Haruka Ikoma, Tatsuya Otaki, Soichiro Yuzuriha, Takato Uchida, Tatsuya Umemoto, Yoshiaki Kawamura and 2 more

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in CEN case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nobuyuki NakajimaDepartment of Urology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan. nn3226@tokai.ac.jp.ORCID 0000-0001-6307-032X
Hiroshi KajiwaraDepartment of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan.
Kenta OkutsuDepartment of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan.
Toshiki SakemuraDepartment of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan.
Haruka IkomaDepartment of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan.
Tatsuya OtakiDepartment of Urology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan.
Soichiro YuzurihaDepartment of Urology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan.
Takato UchidaDepartment of Urology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan.
Tatsuya UmemotoDepartment of Urology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan.
Yoshiaki KawamuraDepartment of Urology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan.
Yohei MasugiDepartment of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan.
Sunao ShojiDepartment of Urology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-to-tumor metastasis (TTM) is a rare clinicopathological phenomenon in which a malignant tumor metastasizes to another distinct neoplasm. Although renal cell carcinoma (RCC) is a frequent recipient tumor, metastasis from breast carcinoma to RCC is extremely rare. A 64-year-old woman with long-standing hormone receptor-positive breast carcinoma presented with a 23-mm enhancing right renal mass. Robot-assisted partial nephrectomy revealed clear cell RCC with intratumoral nests of metastatic breast carcinoma. Immunohistochemistry revealed a reciprocal staining profile: RCC cells were positive for PAX8 and CA9, whereas metastatic breast carcinoma cells expressed CK7 and GATA3 with weak ER positivity. Clear cell RCC may serve as a recipient tumor for breast carcinoma metastasis, emphasizing that TTM should be considered in the differential diagnosis of renal masses in patients with a history of breast carcinoma, even when imaging findings are consistent with conventional RCC.

Indexed as

Breast NeoplasmsCarcinoma, Renal CellKidney NeoplasmsDiagnosis, DifferentialFemaleGATA3 Transcription FactorHumansImmunohistochemistryMiddle AgedNephrectomyGATA3 Transcription FactorBreast carcinomaClear cell renal cell carcinomaHistopathologyImmunohistochemistryTumor-to-tumor metastasis

Identifiers

PMID42518006
PMCPMC13415395

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.