ArticleEuropean journal of pediatrics2026
Pre-IVIG echocardiography enables targeted treatment in infants younger than 6 months with Kawasaki Disease : Echocardiography-based risk stratification in young infants with Kawasaki Disease.
Article in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
The 2024 American Heart Association scientific statement suggests intensification therapy in infants younger than 6 months (< 6 months) with Kawasaki disease (KD) may be beneficial, but indications remain undefined. We hypothesized that pre-IVIG echocardiographic findings could identify infants < 6 months who do not require intensification beyond standard intravenous immunoglobulin (IVIG). This multicenter cohort study in Taiwan (2019-2023) included children with KD who underwent echocardiography before IVIG and received IVIG within 10 days of illness onset. Children receiving early intensification therapy were excluded. Participants were stratified as < 6 months or ≥ 6 months. Echocardiography was performed at four time points: pre-IVIG, days 11-42, weeks 7-8, and 3 months after KD onset. Among 398 children with KD, 44 (11.1%) were younger than 6 months. Infants < 6 months had higher coronary artery aneurysm (CAA) prevalence at diagnosis than older children (52.3% vs 28.5%; OR, 2.74 [95% CI, 1.45-5.18]; P = .001). IVIG within 7 days was associated with lower CAA risk in both groups. Among children with initially normal coronary dimensions, new CAA risk did not differ significantly between younger and older groups (4.8% vs 2.4%; P = .42). Among 21 infants < 6 months without initial CAA, none developed new CAA except one with KD shock syndrome.
conclusionsPre-IVIG echocardiography may help identify infants < 6 months at low risk for subsequent CAA development with standard IVIG treatment. Given the observational nature of this study, larger prospective studies are warranted to confirm these findings. WHAT IS KNOWN: • Infants younger than 6 months with Kawasaki disease (KD) have elevated coronary artery aneurysm (CAA) risk. • The 2024 AHA scientific statement suggests intensification therapy may be beneficial in this age group, but clear indications remain undefined. WHAT IS NEW: • In infants younger than 6 months with KD and normal pre-IVIG coonary dimensions, new coronary artery aneurysms rarely developed during follow-up. • Pre-IVIG echocardiography may help identify infants <6 months at low risks for subsequent CAA development with standard IVIG treatment.
Indexed as
Identifiers
42517909What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.