Evidence map›Paper›PMID 42517686›Full record

Trial reportAmerican journal of hematology2026

Recombinant Human Thrombopoietin Reduces the Need for Platelet Transfusion in Patients With Chronic Liver Disease and Thrombocytopenia.

Yifan Han, Ning Lin, Jinghang Xu, Sikui Wang, Jinglan Jin, Jia Shang, Yongning Xin, Youwen Tan, Dazhi Zhang, Jinlin Hou and 36 more

Abstract readRandomized Controlled TrialMulticenter StudyClinical Trial, Phase III
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

Yifan HanDepartment of Gastroenterology, Peking University First Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-5432-089X
Ning LinDepartment of Infectious Diseases, Peking University First Hospital, Beijing, China.ORCID https://orcid.org/0009-0007-1987-6706
Jinghang XuDepartment of Infectious Diseases, Peking University First Hospital, Beijing, China.ORCID https://orcid.org/0000-0001-8848-3876
Sikui WangDepartment of Infectious Disease, Liaocheng People's Hospital, Shandong, China.
Jinglan JinDepartment of Hepatology, The First Hospital of Jilin University, Jilin, China.
Jia ShangDepartment of Infectious Diseases, Henan Provincial People's Hospital, Henan, China.
Yongning XinDepartment of Hepatology, Qingdao Municipal Hospital, Shandong, China.ORCID https://orcid.org/0000-0002-3692-7655
Youwen TanDepartment of Hepatology, The Third People's Hospital of Zhenjiang, Zhenjiang, China.ORCID https://orcid.org/0000-0002-5464-1407
Dazhi ZhangDepartment of Infectious Disease, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jinlin HouDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangdong, China.ORCID https://orcid.org/0000-0001-8230-8583
Ping AnDepartment of Hepatology, The Sixth People's Hospital of Shenyang, Liaoning, China.
Wen XieCenter of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-7314-8175
Yujuan GuanDepartment of Hepatology, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangdong, China.
Qingfang XiongDepartment of Infectious and Liver Diseases, The Second Hospital of Nanjing, Jiangsu, China.
Hong WuThe Department of Liver Surgery & Liver Transplantation Centre, West China Hospital, Sichuan University, Sichuan, China.
Huiguo DingDepartment of Gastroenterology and Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-8716-4926
Yu ChenFourth Department of Liver Disease Center, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Rongkuan LiDepartment of Infectious Diseases, The Second Hospital of Dalian Medical University, Liaoning, China.ORCID https://orcid.org/0000-0002-2927-7017
Zhili WenDepartment of Gastroenterology, The Second Affiliated Hospital of Nanchang University, Jiangxi, China.
Mingqin LuDepartment of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.ORCID https://orcid.org/0000-0002-8331-5862
Jinhui YangDepartment of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Yunnan, China.
Zhongyin ZhouDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Hubei, China.
Yongjian ZhouDepartment of Gastroenterology, Guangzhou First People's Hospital, Guangdong, China.ORCID https://orcid.org/0000-0003-1721-7639
Zujiang YuDepartment of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Kecan LinDepartment of Hepatopancreatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fujian, China.
Wei WangDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Fujian Medical University, Fujian, China.
Yan HuangDepartment of Infectious Diseases, Xiangya Hospital of Central South University, Hunan, China.
Yuemin NanDepartment of Integrated Traditional Chinese and Western Medicine Hepatology, The Third Hospital of Hebei Medical University, Hebei, China.ORCID https://orcid.org/0000-0003-4192-099X
Xinhua LuoDepartment of Infectious Diseases, Guizhou Provincial People's Hospital, Guizhou, China.
Rongshu ShiDepartment of Intervention, Affiliated Hospital of Zunyi Medical University, Guizhou, China.
Yi KangDepartment of Infectious Diseases, Henan Provincial People's Hospital, Henan, China.
Tao HanDepartment of Hepatology and Gastroenterology, Tianjin People's Hospital, Tianjin, China.ORCID https://orcid.org/0000-0003-4216-6968
Shiyan ChenDepartment of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China.
Kai WangDivision of Hepato-Biliary-Pancreatic Surgery, Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Jiangxi, China.ORCID https://orcid.org/0000-0002-8394-348X
Yunfeng ShanDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Jiaping LiDepartment of Interventional Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong, China.
Pingguo LiuDepartment of Hepatobiliary Surgery, Zhongshan Hospital Xiamen University, Fujian, China.
Zheng LuDepartment of General Surgery, The First Affiliated Hospital of Bengbu Medical University, Anhui, China.
Jun ChenDepartment of Hepatology, Shenzhen Third People's Hospital, Guangdong, China.ORCID https://orcid.org/0000-0002-9744-792X
Zhen LiuDepartment of Hepatobiliary Surgery, Liuzhou People's Hospital, Guangxi, China.
Liaoyun ZhangDepartment of Infectious Diseases, First Hospital of Shanxi Medical University, Shanxi, China.
Li YangDepartment of Gastroenterology, West China Hospital, Sichuan University, Sichuan, China.
Jifang ShengState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China.
Zhan ZengDepartment of Infectious Diseases, Peking University First Hospital, Beijing, China.
Yanyan YuDepartment of Infectious Diseases, Peking University First Hospital, Beijing, China.
Xiaoyuan XuDepartment of Gastroenterology, Peking University First Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-1759-4330

Funding

Beijing iGandan Foundation iGandanF-1082025-RGG024Prevention and Control of Emerging and Major Infectious Diseases-National Science and Technology Major Project 2025ZD01906300Prevention and Control of Emerging and Major Infectious Diseases-National Science and Technology Major Project 2025ZD01906303
6 · The paper itself

Abstract

Chronic liver disease (CLD)-related thrombocytopenia can limit the feasibility of invasive procedures. Recombinant human thrombopoietin (rhTPO) has demonstrated a favorable safety profile without hepatotoxicity. We evaluated the efficacy and safety of rhTPO in patients with CLD-related thrombocytopenia who were undergoing elective invasive procedures. In this multicenter, randomized (2:1), double-blind, placebo-controlled phase III trial, 120 adult Chinese patients with CLD-related thrombocytopenia (platelet count < 50 × 10

Indexed as

Liver DiseasesPlatelet TransfusionThrombocytopeniaThrombopoietinAdultAgedChronic DiseaseDouble-Blind MethodFemaleHumansMaleMiddle AgedPlatelet CountRecombinant ProteinsTreatment OutcomeRecombinant ProteinsThrombopoietinchronic liver diseaseefficacyrecombinant human thrombopoietinsafetythrombocytopenia

Identifiers

PMID42517686
PMCPMC13540341

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.