ArticlePhysiological research2026
Association Between Serum 25(OH)D Concentrations and Glucose-Lipid Metabolism in Women With Gestational Diabetes Mellitus: Analysis of A NHANES 2007-2018.
Article in Physiological research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D is implicated in multiple metabolic processes, however, the dose-dependent relationship between serum 25-hydro-xyvitamin D [25(OH)D] concentrations and glucose-lipid metabolism remains unclear among women with a history of gestational diabetes mellitus (GDM). This study aimed to assess both linear and non-linear relationships between serum 25(OH)D levels and indicators of insulin resistance and lipid metabolism in this high-risk group. Data from 1,876 women with prior GDM were obtained from the 2007-2018 National Health and Nutrition Examination Survey (NHANES). Weighted linear regression models were applied to assess associations between serum 25(OH)D and metabolic markers, while restricted cubic spline models were used to examine non-linear relationships. Analyses were adjusted for age, ethnicity, body mass index (BMI), education, and lifestyle factors. Following multivariate adjustment, each 10 nmol/l increase in serum 25(OH)D was associated with a decrease in HOMA-IR by 0.017 units (95 % CI: -0.026, -0.007), an increase in HDL-C by 0.127 mg/dl (95 % CI: 0.102, 0.153), and a reduction in total cholesterol of 0.007 mmol/l (95 % CI: -0.009, -0.004). Restricted cubic spline analysis demonstrated a U-shaped relationship between 25(OH)D and LDL-C (p for non-linearity<0.001), with inflection point at ~50 nmol/l. The inverse association between 25(OH)D and HOMA-IR was significant in non-Hispanic white individuals (beta=-0.020, p=0.008) but not in non-Hispanic Black individuals (beta=0.009, p=0.584). The positive association between 25(OH)D and HDL-C was strongest in women with normal BMI (beta=0.114). Among women with a history of GDM, serum 25(OH)D levels were inversely associated with insulin resistance and positively associated with HDL-C. A non-linear, U-shaped relationship was observed with LDL-C. These associations varied by race/ethnicity and BMI, the potential relevance of vitamin D status in in the long-term metabolic management of individuals following GDM. Key words 25-hydroxyvitamin D " Dose-response relationship " Gestational diabetes mellitus " Insulin resistance " Lipid metabolism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.