Evidence map›Paper›PMID 42517591›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Interference of ATP-Binding Cassette Transporter by Functional Nano-Delivery System for High Efficiency Management of Insecticide-Resistant Nilaparvata lugens.

Chengshuai He, Hejun Ren, Shuo Zhang, Jikang Cheng, Hui Zhang, Jiao Liu, Sijie Wang, Congfen Gao, Yanchao Zhang, Yunhao Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chengshuai HeState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Hejun RenState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Shuo ZhangState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Jikang ChengState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Hui ZhangState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.ORCID https://orcid.org/0009-0005-3220-458X
Jiao LiuState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Sijie WangState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Congfen GaoState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.ORCID https://orcid.org/0000-0003-1991-0322
Yanchao ZhangState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.ORCID https://orcid.org/0009-0001-9626-1234
Yunhao GaoState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.ORCID https://orcid.org/0009-0006-5263-3362

Funding

Basic Research Program of Jiangsu BK20252051National Key Research and Development Program of China 2021YFD1401105Startup Grant from Nanjing Agricultural University 804146Startup Grant from Nanjing Agricultural University 80900249
6 · The paper itself

Abstract

ATP-binding cassette (ABC) transporters, by mediating drug efflux, have emerged as a major driver of insecticide resistance in agricultural pests, yet direct countermeasures against this defense mechanism remain scarce. Here, we report that zeolitic imidazole framework-90 (ZIF-90) can serve as a functional insecticide carrier to overcome resistance by interfering with ABC transporters. Dinotefuran-loaded ZIF-90 (Din@ZIF-90) was synthesized via a simple and rapid one-pot method and exhibited significantly enhanced toxicity against Din-resistant Nilaparvata lugens. Mechanistically, the nanoformulation selectively inhibited the expression of NlABCG3 and NlABCH1, two ABC transporter genes involved in Din resistance, as validated by RNAi. Molecular docking further confirmed the binding potential of Din with the NlABCG3 and NlABCH1 proteins, establishing their functional roles in efflux-based resistance. In addition, Din@ZIF-90 afforded enhanced photostability, pH/ATP-responsive release, superior leaf adhesion, and preserved systemic movement in rice. The nanoformulation also exhibited markedly lower acute contact toxicity to honeybees and was biocompatible with rice, promoting seedling growth. This work presents a novel nanotechnology-based strategy to combat insecticide resistance through targeted modulation of ABC transporters.

Indexed as

ABC transporterInsecticide resistancenilaparvata lugensZIF‐90

Identifiers

PMID42517591
PMCPMC13410808

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.