Evidence map›Paper›PMID 42517511›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

RGS16 Aggravates Hepatic Ischemia-Reperfusion Injury via Hepatocyte-Intrinsic Apoptosis/Inflammation & Neutrophil Recruitment/NETosis.

Xinglong Li, Zhanzhi Meng, Hongjun Yu, Yongliang Hua, Zihao Li, Bing Yin, Baolin Qian, Zhongyu Li, Yongzhi Zhou, Zhigang Feng and 7 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xinglong LiDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Zhanzhi MengDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Hongjun YuDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yongliang HuaDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Zihao LiDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.ORCID https://orcid.org/0000-0002-4040-8188
Bing YinDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Baolin QianDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Zhongyu LiDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yongzhi ZhouDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Zhigang FengDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Shounan LuDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Shanjia KeDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Miaoyu BaiDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yao FuDepartment of Ultrasound, The First Affiliated Hospital of Harbin Medical University, Harbin, China.ORCID https://orcid.org/0000-0002-3843-3835
Wei TangInternational Health Care Center, National Center for Global Health and Medicine, Tokyo, Japan.
Natalia V BelosludtsevaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.ORCID https://orcid.org/0000-0001-5707-6557
Yong MaDepartment of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.ORCID https://orcid.org/0000-0002-6508-508X

Funding

Chen Xiaoping Foundation for the Development of Science and Technology of Hubei Province CXPJJH11900001-2019349Key Research and Development Program of Heilongjiang Province 2024ZX12C28National Natural Science Foundation of China 82370643National Natural Science Foundation of China 82525068Scientific Foundation of the First Affiliated Hospital of Harbin Medical University HYD2020JQ0007
6 · The paper itself

Abstract

Hepatic ischemia-reperfusion injury (HIRI) is a frequent and severe complication after liver transplantation and hepatectomy, driven by sterile inflammation and lacking effective therapies. Regulator of G-protein signaling 16 (RGS16) is an inflammatory modulator, but its role in HIRI remains unclear. We found that RGS16 expression was markedly increased in the livers of post-hepatectomy patients and positively correlated with neutrophil extracellular trap formation (NETosis). Using hepatocyte-specific Rgs16 knockout and transgenic mouse models, we demonstrated that Rgs16 deficiency attenuated hepatic inflammation and apoptosis after HIRI, whereas Rgs16 overexpression significantly exacerbated liver injury. Integrated multi-omics analyses, including RNA-seq, MeRIP-seq, and mass spectrometry, identified C-X-C motif chemokine ligand 1 (CXCL1) as a key downstream effector of RGS16. Mechanistically, RGS16 competitively binds YTH domain family protein 3 (YTHDF3), displacing poly(A)-nuclease deadenylation complex subunit 3 (PAN3) and stabilizing m

Indexed as

apoptosishepatic ischemia‒reperfusion injuryinflammationneutrophil extracellular trapsregulator of G‐protein signaling 16

Identifiers

PMID42517511
PMCPMC13410803

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.