ArticleNucleus (Austin, Tex.)2026
XPO1-dependent nuclear export regulates NS3 localization and promotes DENV-2 replication through mitochondrial remodeling and interferon suppression.
Article in Nucleus (Austin, Tex.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Nucleocytoplasmic transport is essential for cellular homeostasis and is frequently exploited by viruses during infection. Although dengue virus (DENV) non-structural protein 3 (NS3) undergoes nuclear trafficking, the role of nuclear export pathways in its localization and in viral replication remains poorly understood. Here, we show that pharmacological inhibition of exportin 1 (XPO1) promotes the accumulation of DENV-2 NS3 in both the nucleus and mitochondria of infected Huh-7 cells. XPO1 inhibition also induces mitochondrial morphological alterations resembling those observed during DENV infection. Moreover, blockade of nuclear export enhances DENV-2 replication in interferon-stimulated cells by reducing type I interferon production, suggesting the establishment of a pro-viral cellular environment. Our findings reveal that XPO1-mediated nuclear export contributes to the regulation of NS3 localization and links nuclear export to mitochondrial remodeling and suppression of antiviral signaling during DENV infection.
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