SynthesisJournal of paediatrics and child health2026
Association Between Delivery Room Continuous Positive Airway Pressure and Neonatal Outcomes in Late Preterm and Term Infants: A Systematic Review and Meta-Analysis.
Synthesis in Journal of paediatrics and child health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the effects of delivery room continuous positive airway pressure (DR-CPAP) in late preterm and term infants.
designSystematic review and meta-analysis. DATA SOURCES: Cochrane Library, Embase, Emcare and MEDLINE were searched through March 26, 2025. ELIGIBILITY CRITERIA: Observational studies and randomised clinical trials (RCTs) comparing outcomes in infants receiving DR-CPAP versus no DR-CPAP.
methodsMeta-analyses were conducted using a random-effects model to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs). Risk of bias was assessed per Cochrane guidelines, and certainty of evidence was graded using the GRADE framework. MAIN OUTCOME: Pneumothorax.
resultsSeven studies (five non-randomised, two RCTs) involving 135 472 infants were included. In observational data, DR-CPAP was associated with a significant increased risk of pneumothorax (unadjusted OR: 45.79; 95% CI: 31.47-66.63; moderate certainty; adjusted OR: 24.18; 95% CI: 2.32-251.63; moderate certainty). RCTs reported no pneumothorax events in both groups, preventing meta-analytic estimation. DR-CPAP was also associated with increased use of surfactant in observational studies (OR: 5.68; 95% CI: 2.97-10.86; very low certainty). For neonatal intensive care unit admissions, DR-CPAP was associated with significantly higher odds in observational studies (OR: 14.56; 95% CI: 13.27-15.98; moderate certainty), but significantly lower odds in RCTs (OR: 0.24; 95% CI: 0.09-0.63; very low certainty).
conclusionsDR-CPAP was associated with potential harm in observational studies, though confounding cannot be excluded. Evidence from RCTs remains limited, and is of very low certainty. Well-designed, robust clinical studies are urgently needed to guide practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.