Shelf-Stable, Rapid-Gelling, and Robust Thrombin-Independent Fibrinogen-Based Hydrogels for Massive Hemorrhage Control.

Yihang Ding, Zhaodi Liu, Xizhuo Jing, Ruifen Yang, Zhiliang Huang, Lisha Yu, Zhengwei Mao

Abstract read

In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yihang DingMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.

Zhaodi LiuKey Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, China.

Xizhuo JingMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.

Ruifen YangMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.

Zhiliang HuangDepartment of Ultrasonography, Shulan (Hangzhou) Hospital, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China.

Lisha YuKey Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, China.

Zhengwei MaoMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0000-0001-7990-2856

Funding

Joint Fund of Zhejiang Provincial Natural Science Foundation of China LKLZ26H180002Key Research and Development Program of Zhejiang Province 2025C02134National Natural Science Foundation of China 32571525National Natural Science Foundation of China 52425305

6 · The paper itself

Abstract

Effective hemorrhage control remains an important unmet need in trauma care and emergency medicine. Therefore, it is essential to achieve rapid and effective hemostasis. Bioadhesives offer an attractive approach to wound sealing, achieving simultaneous leakage prevention, mechanical support, and hemostasis. However, available bioadhesives are limited in clinical applications by weak mechanical strength, insufficient biocompatibility, and strict storage condition. In this study, a thrombin-independent fibrinogen-based hydrogel was developed, featuring rapid gelation, robust mechanical strength, strong tissue adhesion, and excellent shelf stability. This hydrogel is prepared from knob-peptide-grafted gelatin methacryloyl (GMK) and fibrinogen methacryloyl (FM). GMK/FM hydrogel can quickly form the knob-hole crosslinking and then be reinforced through photo-crosslinking. Compared with clinical standard-of-care fibrin glue, GMK/FM hydrogel demonstrates comparably rapid gelation (< 2 s), alongside enhanced mechanical strength, tissue adhesion and storage stability (4 weeks at room temperature). In rat severe hemorrhage models of liver and abdominal aorta, GMK/FM hydrogel decreased hemostatic time and blood loss remarkably. It demonstrates exceptional hemostatic performance, outstanding biocompatibility, and storage stability, holding significant promise for clinical applications and emergency uses.

Indexed as

FibrinogenHemorrhageHydrogelsThrombinAnimalsGelatinHemostaticsHumansMaleMethacrylatesRatsRats, Sprague-DawleyFibrinogenGelatingelatin methacryloylHemostaticsHydrogelsMethacrylatesThrombinmassive hemorrhageprotein hydrogelrapid gelationtissue adhesion

Identifiers

PMID42517240

DOI10.1002/adhm.71483

PMCPMC13507611

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.