Evidence map›Paper›PMID 42517165›Full record

Observational studyEuropean journal of physical and rehabilitation medicine2026

Temporal trajectory and predictors of hemiplegic shoulder pain after stroke: a 12-month longitudinal clinical-ultrasound study.

Filippo Cotellessa, Maria C May, Valentina Guzzone, Luca Puce, Riccardo Picasso, Riccardo Pedrini, Laura Mori, Alessandra Murialdo, Davide Sassos, Carlo Trompetto and 2 more

Abstract readObservational Study
In one paragraph

Observational study in European journal of physical and rehabilitation medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Filippo CotellessaDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Maria C MayIRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy.
Valentina GuzzoneIRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy.
Luca PuceDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy - luca1puce@gmail.com.
Riccardo PicassoIRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy.
Riccardo PedriniIRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy.
Laura MoriDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Alessandra MurialdoIRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy.
Davide SassosIRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy.
Carlo TrompettoDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Matteo FormicaIRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy.
William CampanellaIRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHemiplegic shoulder pain (HSP) is a frequent complication after stroke. Although HSP is considered a multifactorial condition, the temporal sequence through which different mechanisms contribute to pain remains poorly understood, mainly due to the lack of longitudinal studies starting from the acute phase and integrating imaging data.

aimTo describe the 12-month temporal trajectory of hemiplegic shoulder pain after stroke and to identify time-specific clinical and ultrasonographic predictors of pain intensity.

designProspective Longitudinal Observational Study.

settingInpatient stroke unit and neurorehabilitation facilities. POPULATION: Patients with first-ever ischemic or hemorrhagic stroke and contralateral hemiparesis.

methodsPatients were evaluated within 72 hours after stroke onset and at 1, 3, 6, and 12 months. Shoulder pain during passive mobilization was assessed using the Numerical Rating Scale. Clinical evaluation and standardized shoulder ultrasonography were performed at each time point. Univariable and multivariable linear regression analyses identified independent predictors of pain.

resultsSeventy-seven patients were enrolled. Pain increased from the acute phase to a peak at 3 months and progressively decreased thereafter. Reduced passive range of motion was consistently associated with pain. In the acute phase, pain was associated with glenohumeral subluxation. Adhesive capsulitis emerged at 1 month, while at 3 months pain was associated with subluxation, capsulitis, and tendon tears. In the chronic phase, tendon tears became the main determinant of residual pain.

conclusionsHemiplegic shoulder pain follows a temporally differentiated multifactorial pattern, with distinct mechanisms prevailing at different stages after stroke. CLINICAL REHABILITATION IMPACT: Identifying phase-specific mechanisms of hemiplegic shoulder pain supports targeted, time-specific preventive and therapeutic strategies in neurorehabilitation.

Indexed as

HemiplegiaShoulder PainStrokeAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedPain MeasurementProspective StudiesRange of Motion, ArticularTime FactorsUltrasonography

Identifiers

PMID42517165
PMCPMC13436733

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.