ReviewFrontiers in psychiatry2026
Circuit-based neuromodulation for obsessive-compulsive disorder: a review of prior and emerging methods.
Review in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Obsessive-compulsive disorder (OCD) is a psychiatric disorder characterized by intrusive and distressing thoughts (obsessions) and repetitive/ritualistic behaviors (compulsions). OCD pathophysiology is thought to arise from dysregulated cortico-striato-thalamo-cortical (CSTC) loops between cognitive and affective circuits. Clinically effective neurosurgical lesions such as cingulotomy and capsulotomy provide insight into mapping distinct symptoms to circuits, and more modern neuromodulation techniques such as transcranial magnetic stimulation (TMS), deep brain stimulation (DBS), and focused ultrasound (FUS) provide the opportunity to develop more precise interventions. We review the literature for neuromodulatory interventions for OCD with a focus on identifying common circuits across modalities. Future directions such as closed-loop DBS and more precisely identifying symptom subtypes are also discussed.
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