Case Report: Deep brain stimulation in SYNJ1-related early-onset parkinsonism.

Jiali Liu, Youcheng Zhang, Shouxuan Chen, Bin Xu, Zhengzheng Huang, Liping Zhou, Xin Zheng

Abstract readCase Reports

In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiali Liu *Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.

Youcheng Zhang *Faculty of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Shouxuan ChenDepartment of Neurology, South China Hospital of Shenzhen University, Shenzhen, China.

Bin XuDepartment of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.

Zhengzheng HuangDepartment of Neurology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.

Liping ZhouResearch Centre for Chinese Medicine Innovation (RCMI), The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.

Xin ZhengDepartment of Neurology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Deep brain stimulation (DBS) is established for levodopa-responsive Parkinson's disease (PD), but the outcomes of DBS in rare genetic early-onset parkinsonism remain incompletely defined. While its efficacy is documented in monogenic forms of parkinsonism (e.g., Case presentation: We report two patients with Conclusion: These cases illustrate heterogeneous clinical responses to DBS in patients with early-onset parkinsonism carrying SYNJ1 variants. DBS may provide symptomatic benefit in carefully selected patients, but the small sample size and variant-level uncertainty preclude conclusions regarding genotype-specific efficacy.

Indexed as

atypical Parkinson’s diseasedeep brain stimulationearly-onset parkinsonismmonogenic ParkinsonismsSYNJ1 gene

Identifiers

PMID42517031

DOI10.3389/fmed.2026.1895449

PMCPMC13402543

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.