ArticleEJHaem2026
Variables Affecting Periprocedural Haemostatic Response in Patients With Haemophilia: Real-World Retrospective Study.
Article in EJHaem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Introduction: Patients with haemophilia (PWH) undergoing invasive procedures are at increased risk of periprocedural bleeding, and optimal haemostatic response (HR) depends on patient- and procedure-related factors. We aimed to evaluate variables associated with HR in PWH undergoing invasive procedures. Methods: We performed a retrospective, single-centre study of all invasive procedures in males with haemophilia A or B recorded in a regional reference centre database (2010-2025). Data from electronic records included age, body weight, haemophilia type and severity, inhibitor status, prophylaxis regimen and haemostatic product, pre-procedural haemostatic preparation, genetic mutation (when available) and procedure characteristics. HR was assessed using World Federation of Haemophilia criteria and dichotomised as good/excellent versus fair/poor. Categorical comparisons were performed using Fisher's exact test or Fisher-Freeman-Halton exact tests. Continuous sensitivity analyses were also performed. Results: Overall, 158 procedures were performed in 61 patients. HR was good/excellent in 151/158 procedures (95.6%) and fair/poor in 7/158 (4.4%). Fair/poor HR occurred in 3/11 procedures (27.3%) in patients weighing >100 kg, compared with 1/87 (1.1%) in those weighing 61-100 kg and 2/51 (3.9%) in those ≤ 60 kg (exact Conclusion: High body weight may be associated with suboptimal HR in PWH undergoing invasive procedures, supporting targeted strategies to address overweight and obesity. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.
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