ArticleInfection and drug resistance2026
Real-World Clinical Outcomes of Sulbactam-Durlobactam Against Carbapenem-Resistant
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Sulbactam-durlobactam (SUL-DUR) was approved in China in 2024 for the treatment of carbapenem-resistant Methods: We conducted a multicenter, retrospective case series across three hospitals in Hubei Province, China (January 2025 - March 2026), to evaluate the clinical efficacy, safety, and preliminary pharmacoeconomic profiles of SUL-DUR in patients with CRAB infections. Results: Twenty-one patients were included; SUL-DUR was administered as primary (n=12) or salvage (n=9) therapy. Infections primarily involved the respiratory tract (n=20) and bloodstream (n=3). Genetic profiling of available isolates (n=18) identified OXA-23 (94.4%) as the predominant Conclusion: SUL-DUR, administered exclusively as part of combination regimens, was associated with favorable clinical outcomes and a manageable short-term safety profile in this small cohort, including in patients requiring extracorporeal life support and those infected with strains co-harboring multiple
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