Evidence map›Paper›PMID 42516908›Full record

ArticleERJ open research2026

Diagnostic value of EBUS-guided transbronchial mediastinal cryobiopsy

Zhuofan Li, Quncheng Zhang, Fei Tang, Ye Fan, Mingming Deng, Yunchao Su, Ziwen Zheng, Run Tong, Guowu Zhou, José M Porcel and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhuofan LiNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, and Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, PR China.
Quncheng ZhangDepartment of Respiratory and Critical Care Medicine, Zhengzhou University People's Hospital, and Henan Provincial People's Hospital, Zhengzhou, PR China.
Fei TangDepartment of Interventional Pulmonology and Endoscopic Diagnosis and Treatment Center, Anhui Chest Hospital, Hefei, PR China.
Ye FanDepartment of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, PR China.
Mingming DengNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, and Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, PR China.
Yunchao SuDepartment of Pathology, China-Japan Friendship Hospital, Beijing, PR China.
Ziwen ZhengNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, and Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, PR China.ORCID https://orcid.org/0000-0003-1711-6328
Run TongNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, and Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, PR China.
Guowu ZhouNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, and Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, PR China.
José M PorcelPleural Medicine and Clinical Ultrasound Unit, Department of Internal Medicine, Arnau de Vilanova University Hospital, IRBLleida, University of Lleida, Lleida, Spain.ORCID https://orcid.org/0000-0002-2734-8061
Gang HouNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, and Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, PR China.ORCID https://orcid.org/0000-0003-3438-1764

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rationale and objectives: A direct comparison between endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), combined with endobronchial biopsy (EBB) and/or transbronchial lung biopsy (TBLB), and endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy (EBUS-TBMC) for diagnosing sarcoidosis has not been conducted. The aim of the study was to evaluate whether EBUS-TBMC has the same or better diagnostic yield for sarcoidosis than EBUS-TBNA combined with standard bronchoscopic modalities (EBB and/or TBLB). Methods: The records of patients with stage I/II sarcoidosis from four centres in China who underwent EBUS-TBMC or EBUS-TBNA combined with EBB and/or TBLB were retrospectively examined. Data on bronchoscopy examination records, pathological results of bronchoscopic biopsy modalities and postprocedural complications were collected. The outcomes were diagnostic yield and postprocedural complications. Measurements and main results: A total of 438 patients were included in this study. Compared with EBUS-TBNA, EBUS-TBMC had greater diagnostic yield for sarcoidosis (95.1% Conclusions: EBUS-TBMC exhibited diagnostic yield equivalent to that of EBUS-TBNA combined with EBB and/or TBLB, and superior to that of EBUS-TBNA alone in stage I/II sarcoidosis. The addition of EBB and/or TBLB to EBUS-TBMC did not improve the diagnostic yield of EBUS-TBMC for sarcoidosis. EBUS-TBMC has the potential to reduce the need for EBB and TBLB.

Identifiers

PMID42516908
PMCPMC13402998

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.