ArticleFrontiers in global women's health2026
The
Article in Frontiers in global women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 authors.
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Abstract
Background: Miscarriage affects 15%-20% of clinically recognized pregnancies, yet reliable biomarkers for risk stratification remain elusive. While systemic inflammatory markers derived from routine complete blood count have shown promise in identifying associations with adverse pregnancy outcomes, their association with miscarriage has not been systematically evaluated. Methods: In this retrospective cohort study of 347 pregnant women with a history of at least one prior pregnancy loss, we calculated neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) from routine complete blood count tests. Associations with miscarriage were evaluated using four progressively adjusted logistic regression models accounting for demographic, reproductive, and metabolic confounders. Dose-response relationships were assessed through quartile analysis, threshold effects through piecewise linear regression, and non-linear associations through generalized additive models. Results: After comprehensive adjustment, higher NLR was independently associated with reduced miscarriage risk (OR = 0.67 per doubling, 95%CI: 0.49-0.91, Conclusions: Among women with a history of prior pregnancy loss, NLR and LMR were independently associated with miscarriage in opposing directions, consistent with a
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