ArticleNorthern clinics of Istanbul2026
Evaluation of the relationship between combined scores derived from pre-operative routine parameters and weight loss following sleeve gastrectomy: A retrospective cohort study.
Article in Northern clinics of Istanbul, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aimed to investigate whether pre-operative composite indices derived from routine laboratory parameters, namely the fibrosis-4 (FIB-4) index, the aspartate aminotransferase-to-platelet ratio index (APRI), and the homeostatic model assessment of insulin resistance (HOMA-IR), were associated with post-operative percentage of excess weight loss (%EWL) after laparoscopic sleeve gastrectomy (LSG).
methodsThis retrospective cohort study included 91 adults who underwent LSG at a tertiary referral center. Pre-operative FIB-4, APRI, and HOMA-IR values were calculated from routinely obtained clinical and biochemical parameters. The primary endpoint was %EWL during post-operative follow-up. Patients were also classified as successful (%EWL ≥50%) or suboptimal (%EWL <50%) responders. Comparative analyses, correlation analyses, and multivariable linear regression were performed.
resultsThe cohort had a mean age of 39.2±10.0 years and was predominantly female (80.2%). Mean baseline body mass index (BMI) was 45.1±6.3 kg/m
conclusionPre-operative FIB-4, APRI, and HOMA-IR appear valuable for metabolic and hepatic phenotyping before surgery, but they do not provide sufficient standalone prognostic discrimination for early post-operative %EWL after LSG. Baseline adiposity may remain more informative than these composite indices for identifying patients at risk of suboptimal relative weight loss.
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