Evidence map›Paper›PMID 42516770›Full record

ArticleOxford medical case reports2026

Case report of invasive lobular carcinoma with pineal metastasis.

Masayuki Saito, Kanna Ozaki, Hirona Banno, Mirai Ido, Manami Goto, Takahito Ando, Yukako Mouri, Junko Kousaka, Kimihito Fujii, Tsuneo Imai and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxford medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Masayuki SaitoDivision of Breast and Endocrine Surgery, Department of Surgery, Aichi Medical University, 1-1, Yazakokarimata, Nagakute-city, Aichi, 480-1195, Japan.ORCID https://orcid.org/0009-0006-5279-8167
Kanna OzakiDivision of Breast and Endocrine Surgery, Department of Surgery, Aichi Medical University, 1-1, Yazakokarimata, Nagakute-city, Aichi, 480-1195, Japan.
Hirona BannoDivision of Breast and Endocrine Surgery, Department of Surgery, Aichi Medical University, 1-1, Yazakokarimata, Nagakute-city, Aichi, 480-1195, Japan.
Mirai IdoDivision of Breast and Endocrine Surgery, Department of Surgery, Aichi Medical University, 1-1, Yazakokarimata, Nagakute-city, Aichi, 480-1195, Japan.
Manami GotoDivision of Breast and Endocrine Surgery, Department of Surgery, Aichi Medical University, 1-1, Yazakokarimata, Nagakute-city, Aichi, 480-1195, Japan.
Takahito AndoDivision of Breast and Endocrine Surgery, Department of Surgery, Aichi Medical University, 1-1, Yazakokarimata, Nagakute-city, Aichi, 480-1195, Japan.
Yukako MouriDivision of Breast and Endocrine Surgery, Department of Surgery, Aichi Medical University, 1-1, Yazakokarimata, Nagakute-city, Aichi, 480-1195, Japan.ORCID https://orcid.org/0009-0003-1352-003X
Junko KousakaDivision of Breast and Endocrine Surgery, Department of Surgery, Aichi Medical University, 1-1, Yazakokarimata, Nagakute-city, Aichi, 480-1195, Japan.
Kimihito FujiiDivision of Breast and Endocrine Surgery, Department of Surgery, Aichi Medical University, 1-1, Yazakokarimata, Nagakute-city, Aichi, 480-1195, Japan.
Tsuneo ImaiDivision of Breast and Endocrine Surgery, Department of Surgery, Aichi Medical University, 1-1, Yazakokarimata, Nagakute-city, Aichi, 480-1195, Japan.
Shogo NakanoDivision of Breast and Endocrine Surgery, Department of Surgery, Aichi Medical University, 1-1, Yazakokarimata, Nagakute-city, Aichi, 480-1195, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 59-year-old woman was diagnosed with luminal-type invasive lobular carcinoma (ILC) of the breast, cT3N3bM0, cStage IIIC. After neoadjuvant chemotherapy, she underwent mastectomy and axillary lymph node dissection, and pathological examination revealed ypT3N0M0, ypStage IIB. She subsequently received postmastectomy radiation therapy and endocrine therapy. Nine months after surgery, she developed multiple bone metastases, followed one month later by headache and diplopia. Brain magnetic resonance imaging revealed lesions in the occipital lobe, cerebellum, and pineal gland. Endoscopic biopsy confirmed pineal metastasis of ILC with subtype conversion to triple-negative breast cancer. Whole-brain radiation therapy with local boost irradiation was administered, followed by systemic chemotherapy. Comprehensive genomic profiling revealed high tumor mutational burden. This case highlights the clinical value of biopsy for atypical brain metastases in guiding therapeutic decision-making.

Indexed as

breast cancercomprehensive genomic profilinginvasive lobular carcinomapineal metastasisradiation therapy

Identifiers

PMID42516770
PMCPMC13403554

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.