ArticleBrain communications2026
Recovery in pupillometric non-visual functions following chiasmal decompression in pituitary adenoma.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Pituitary adenomas frequently compress visual and non-visual pathways, resulting in visual field deficits and sleep disturbances. While transsphenoidal surgery is often anatomically effective, functional visual and non-visual outcomes remain variable and often unpredictable. This study investigates visual and non-visual (i.e. pupillometric) changes associated with optic nerve compression and decompression and the potential role of chromatic pupillometry as an objective evaluation tool for visual dysfunction in pituitary adenoma. This longitudinal study included 27 patients with pituitary adenoma [median age = 55.4 years (interquartile range = 23.4)] and 41 age-matched controls [53.6 (13.7) years], evaluated pre-operatively (mean duration ± SD: 7.0 ± 5.4 weeks prior to surgery) and post-operatively (12.0 ± 1.5 weeks post-surgery) with handheld chromatic pupillometry, in addition to comprehensive neuro-ophthalmological and neuroimaging examinations. Pupillometric features were analysed for associations with structural changes and visual outcomes. There was a significant reduction in the upward displacement and increase in the thickness of the optic chiasm measured on MRI (
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