Evidence map›Paper›PMID 42516725›Full record

ArticleJournal of global infectious diseases

Immunological Evidence of Latent Tuberculosis Infection among Noncontacts and Contacts with Index Tuberculosis Patients.

Ajoy Kumar Verma, Raj Narayan Yadav, Lokender Kumar, Nawaid Hussain Khan, Ashish Ranjan, Rajesh Kumar, Gavish Kumar, Shashikala Panchal, Ravindra Kumar Dewan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of global infectious diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ajoy Kumar VermaDepartment of Microbiology, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India.
Raj Narayan YadavDepartment of Microbiology, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India.
Lokender KumarDepartment of Respiratory Critical Care, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India.
Nawaid Hussain KhanFaculty of Medicine, Ala-Too International University, Bishkek, Kyrgyz.
Ashish RanjanDepartment of Respiratory Critical Care, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India.
Rajesh KumarDepartment of Respiratory Critical Care, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India.
Gavish KumarDepartment of Microbiology, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India.
Shashikala PanchalDepartment of Microbiology, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India.
Ravindra Kumar DewanDepartment of Thoracic Surgery and Surgical Anatomy, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Detecting latent tuberculosis infection (LTBI) is becoming more important in cases where the risk of disease progression is high and where anti-tuberculosis (TB) treatment is necessary. The aim of this study is to find out the immunological evidence of LTBI in terms of release of interferon-gamma (IFN-γ), using interferon-gamma release assays (IGRAs) in contacts with the index TB case and without contact individuals. Methods: This cross-sectional study was conducted from March 2023 to January 2024. Participants were recruited according to the inclusion and exclusion criteria, and written informed consent was obtained. Two IGRAs, QuantiFERON-TB Gold In-Tube (QFT-GIT) Results: Out of 175 participants, immunological evidence of LTBI was observed in 57 (32.5%) on either assay. By QFT-GIT Conclusions: The study revealed that the positivity of the IGRA test between the contact and noncontact groups is statistically not significant. The study findings suggest that IGRA testing for LTBI could be reliable for the high-risk group rather than general screening.

Indexed as

Close contactsinterferon-gamma release assayslatent tuberculosis infectionlateral flow assay

Identifiers

PMID42516725
PMCPMC13405459

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.