Evidence map›Paper›PMID 42516695›Full record

ArticlePulmonary circulation2026

Nocturnal Cerebral Oxygenation in Low-Altitude Residents With Pulmonary Vascular Disease Staying Overnight at High Altitude. Data From a Randomized, Controlled, Crossover Trial.

Carolin Kränzle, Vera Bissig, Simon R Schneider, Julian Müller, Kay von Gruenigen, Meret Bauer, Laura Mayer, Lea Lüönd, Tanja Ulrich, Aglaia Forrer and 6 more

Abstract read
In one paragraph

Article in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Carolin KränzleClinic of Pulmonology University Hospital Zurich Zurich Switzerland.ORCID https://orcid.org/0009-0006-4764-848X
Vera BissigClinic of Pulmonology University Hospital Zurich Zurich Switzerland.
Simon R SchneiderClinic of Pulmonology University Hospital Zurich Zurich Switzerland.
Julian MüllerClinic of Pulmonology University Hospital Zurich Zurich Switzerland.
Kay von GruenigenClinic of Pulmonology University Hospital Zurich Zurich Switzerland.
Meret BauerClinic of Pulmonology University Hospital Zurich Zurich Switzerland.
Laura MayerClinic of Pulmonology University Hospital Zurich Zurich Switzerland.
Lea LüöndClinic of Pulmonology University Hospital Zurich Zurich Switzerland.
Tanja UlrichClinic of Pulmonology University Hospital Zurich Zurich Switzerland.
Aglaia ForrerClinic of Pulmonology University Hospital Zurich Zurich Switzerland.
Arcangelo CartaClinic of Pulmonology University Hospital Zurich Zurich Switzerland.
Ester I SchwarzClinic of Pulmonology University Hospital Zurich Zurich Switzerland.
Konrad E BlochClinic of Pulmonology University Hospital Zurich Zurich Switzerland.
Mona LichtblauClinic of Pulmonology University Hospital Zurich Zurich Switzerland.
Michael FurianClinic of Pulmonology University Hospital Zurich Zurich Switzerland.
Silvia UlrichClinic of Pulmonology University Hospital Zurich Zurich Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whether hypoxia during popular high-altitude travel negatively affects cerebral oxygenation in vulnerable patients with pulmonary vascular disease (PVD) is unknown. We studied overnight cerebral tissue oxygen saturation (CTO) and desaturation index (cODI) in PVD-patients at 2500 m and effects of supplemental oxygen therapy (SOT). In this randomized-controlled crossover trial, stable PVD-patients diagnosed with pulmonary arterial or distal chronic thromboembolic pulmonary hypertension (PAH/CTEPH) had CTO and cODI (decrease in CTO ≥ 4%) assessed overnight at 470 m and 2500 m along with fingertip pulseoximetry (SpO

Identifiers

PMID42516695
PMCPMC13404777

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.