Evidence map›Paper›PMID 42516692›Full record

ArticlePulmonary circulation2026

Pulmonary Veno-Occlusive Disease: A Focused Clinicopathologic Series.

Yub Raj Sedhai, Zein Kattih, Christopher A Thomas, Junad M Chowdhury, Anju Singhal, Alan S Nyquist, Jared D Wilkinson, Haresh Mani, Vikramjit Khangoora, Christopher S King and 3 more

Abstract read
In one paragraph

Article in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yub Raj SedhaiAdvanced Lung Disease and Transplant Program Inova Heart and Vascular Institute, Inova Fairfax Hospital Falls Church Virginia United States.ORCID https://orcid.org/0000-0002-1755-5489
Zein KattihAdvanced Lung Disease and Transplant Program Inova Heart and Vascular Institute, Inova Fairfax Hospital Falls Church Virginia United States.ORCID https://orcid.org/0000-0002-9486-1674
Christopher A ThomasAdvanced Lung Disease and Transplant Program Inova Heart and Vascular Institute, Inova Fairfax Hospital Falls Church Virginia United States.ORCID https://orcid.org/0000-0001-7033-2404
Junad M ChowdhuryAdvanced Lung Disease and Transplant Program Inova Heart and Vascular Institute, Inova Fairfax Hospital Falls Church Virginia United States.ORCID https://orcid.org/0000-0002-1069-0661
Anju SinghalAdvanced Lung Disease and Transplant Program Inova Heart and Vascular Institute, Inova Fairfax Hospital Falls Church Virginia United States.ORCID https://orcid.org/0000-0003-3895-7580
Alan S NyquistAdvanced Lung Disease and Transplant Program Inova Heart and Vascular Institute, Inova Fairfax Hospital Falls Church Virginia United States.ORCID https://orcid.org/0000-0002-2809-2416
Jared D WilkinsonAdvanced Lung Disease and Transplant Program Inova Heart and Vascular Institute, Inova Fairfax Hospital Falls Church Virginia United States.ORCID https://orcid.org/0009-0007-1336-8452
Haresh ManiDepartment of Pathology Inova Fairfax Hospital Falls Church Virginia United States.
Vikramjit KhangooraAdvanced Lung Disease and Transplant Program Inova Heart and Vascular Institute, Inova Fairfax Hospital Falls Church Virginia United States.
Christopher S KingAdvanced Lung Disease and Transplant Program Inova Heart and Vascular Institute, Inova Fairfax Hospital Falls Church Virginia United States.ORCID https://orcid.org/0000-0003-3101-319X
Oksana A ShlobinAdvanced Lung Disease and Transplant Program Inova Heart and Vascular Institute, Inova Fairfax Hospital Falls Church Virginia United States.ORCID https://orcid.org/0000-0003-4131-8499
Steven D NathanAdvanced Lung Disease and Transplant Program Inova Heart and Vascular Institute, Inova Fairfax Hospital Falls Church Virginia United States.ORCID https://orcid.org/0000-0002-6270-1617
Shambhu AryalAdvanced Lung Disease and Transplant Program Inova Heart and Vascular Institute, Inova Fairfax Hospital Falls Church Virginia United States.ORCID https://orcid.org/0000-0002-3753-4378

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary veno-occlusive disease (PVOD) is a rare and aggressive subtype of pulmonary arterial hypertension characterized by fibroproliferative obstruction of post-capillary pulmonary venules leading to increased pulmonary vascular resistance and progressive right ventricular failure. Heritable forms are linked to eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4) mutations, while acquired cases have been associated with environmental exposures, including organic solvents and chemotherapeutic agents like mitomycin-C. PVOD is classified under Group 1 pulmonary hypertension in the current World Symposium on Pulmonary Hypertension classification; however, pulmonary vasodilator therapy has limited efficacy due to the frequent occurrence of acute pulmonary edema.

Indexed as

lung transplantationpulmonary hypertensionpulmonary veno‐occlusive disease

Identifiers

PMID42516692
PMCPMC13404766

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.