Evidence map›Paper›PMID 42516691›Full record

ArticlePulmonary circulation2026

Functional Role of Piezo1 in Regulating Whole-Lung Vascular Reactivity.

Sophia Parmisano, Jiyuan Chen, Yuqin Chen, Pritesh P Jain, Lauren Yung, Wei-Ting Wang, Ting Wang, Xiang Li, Angela Balistrieri, Sophia A Ferrizzi and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sophia ParmisanoDepartment of Medicine University of California, San Diego La Jolla CA USA.
Jiyuan ChenDepartment of Medicine University of California, San Diego La Jolla CA USA.
Yuqin ChenDepartment of Medicine University of California, San Diego La Jolla CA USA.
Pritesh P JainDepartment of Medicine University of California, San Diego La Jolla CA USA.
Lauren YungDepartment of Medicine University of California, San Diego La Jolla CA USA.
Wei-Ting WangDepartment of Medicine University of California, San Diego La Jolla CA USA.ORCID https://orcid.org/0000-0003-4879-4260
Ting WangDepartment of Medicine University of California, San Diego La Jolla CA USA.ORCID https://orcid.org/0000-0001-5512-8026
Xiang LiDepartment of Medicine University of California, San Diego La Jolla CA USA.
Angela BalistrieriDepartment of Medicine University of California, San Diego La Jolla CA USA.
Sophia A FerrizziCenter for Inflammation Science and Systems Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology University of Florida Jupiter FL USA.
Cassia PedronCenter for Inflammation Science and Systems Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology University of Florida Jupiter FL USA.
Owen BrooksCenter for Inflammation Science and Systems Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology University of Florida Jupiter FL USA.
Mona AlotaibiDepartment of Medicine University of California, San Diego La Jolla CA USA.
Jian WangDepartment of Medicine University of California, San Diego La Jolla CA USA.ORCID https://orcid.org/0000-0002-1278-256X
Joe G N GarciaCenter for Inflammation Science and Systems Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology University of Florida Jupiter FL USA.ORCID https://orcid.org/0000-0002-6934-0420
Patricia A ThistlethwaiteDepartment of Surgery University of California, San Diego La Jolla CA USA.
Ayako MakinoDepartment of Medicine University of California, San Diego La Jolla CA USA.
Jason X-J YuanDepartment of Medicine University of California, San Diego La Jolla CA USA.

Funding

Ion Channels and Membrane Receptors in Pulmonary Arterial HypertensionR35HL171538 · NHLBI · UNIVERSITY OF FLORIDA · PI Jason X J Yuan · 2024 to 2026
$3.8M
NHLBI NIH HHS R35 HL171538
6 · The paper itself

Abstract

Mechanosensitive cation channels expressed in pulmonary arterial smooth muscle (SMC) and endothelial (EC) cells contribute to the regulation of vasoconstriction and vasodilation of the pulmonary vasculature. Here, we report that activating Piezo1, a mechanosensitive cation channel, with Yoda1 induced a mild increase in pulmonary arterial pressure (PAP) via vasoconstriction in the intact pulmonary vascular system. Inhibition of nitric oxide (NO) synthase (NOS) with l-NAME significantly potentiated Yoda1-mediated pulmonary vasoconstriction. The Yoda1-mediated vasoconstriction was inhibited by Gd

Indexed as

calcium ionendothelium‐dependent vasodilationmechanosensitive cation channelpulmonary vasoconstrictionYoda1

Identifiers

PMID42516691
PMCPMC13404782

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.