Evidence map›Paper›PMID 42516682›Full record

ArticlePulmonary circulation2026

Iron Homeostasis at High Altitude in Patients With Pulmonary Hypertension.

Aurelia E Reiser, Markus Thiersch, Max Gassmann, Simon R Schneider, Laura Mayer, Stéphanie Saxer, Michael Furian, Richard Sparla, Esther I Schwarz, Mona Lichtblau and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aurelia E ReiserInstitute of Veterinary Physiology Vetsuisse Faculty, University of Zürich Zurich Switzerland.ORCID https://orcid.org/0000-0002-1079-7637
Markus ThierschInstitute of Veterinary Physiology Vetsuisse Faculty, University of Zürich Zurich Switzerland.ORCID https://orcid.org/0000-0002-9118-8285
Max GassmannInstitute of Veterinary Physiology Vetsuisse Faculty, University of Zürich Zurich Switzerland.
Simon R SchneiderInstitute of Veterinary Physiology Vetsuisse Faculty, University of Zürich Zurich Switzerland.
Laura MayerClinic of Pulmonology University Hospital of Zurich Zurich Switzerland.
Stéphanie SaxerClinic of Pulmonology University Hospital of Zurich Zurich Switzerland.
Michael FurianClinic of Pulmonology University Hospital of Zurich Zurich Switzerland.
Richard SparlaDepartment of Pediatric Hematology, Oncology, and Immunology, University of Heidelberg, Heidelberg, Germany, Molecular Medicine Partnership Unit (MMPU), European Molecular Biology Laboratory and University of Heidelberg, Heidelberg, Germany, German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany, Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL) University of Heidelberg Heidelberg Germany.
Esther I SchwarzClinic of Pulmonology University Hospital of Zurich Zurich Switzerland.
Mona LichtblauClinic of Pulmonology University Hospital of Zurich Zurich Switzerland.
Martina U MuckenthalerDepartment of Pediatric Hematology, Oncology, and Immunology, University of Heidelberg, Heidelberg, Germany, Molecular Medicine Partnership Unit (MMPU), European Molecular Biology Laboratory and University of Heidelberg, Heidelberg, Germany, German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany, Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL) University of Heidelberg Heidelberg Germany.
Silvia UlrichClinic of Pulmonology University Hospital of Zurich Zurich Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron deficiency aggravates hypoxic pulmonary vasoconstriction, exacerbating the increase of pulmonary arterial pressure at high altitude (HA). This may be especially relevant for patients with pulmonary hypertension (PH) travelling to HA, who moreover have a high prevalence of iron deficiency. Currently, no data is available on iron parameters and their influence on HA adaptation in PH-patients. In a randomized cross-over trial, 27 patients (44% female, mean age 61.7 ± 13.6 y) with pulmonary arterial hypertension (67%) or chronic thromboembolic PH (33%) were assessed at baseline (Zurich, 470 m) and during a stay at 2500 m. Blood samples were taken at baseline and after 20 h at 2500 m. A significant increase in ferritin (131 ± 68 to 140 ± 75,

Indexed as

chronic thromboembolic pulmonary hypertensionhypoxiapulmonary arterial hypertensiontransferrin

Identifiers

PMID42516682
PMCPMC13404762

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.