Evidence map›Paper›PMID 42516677›Full record

ArticlePulmonary circulation2026

Poncirin Alleviates Hypoxic Pulmonary Hypertension by Blocking TDP43-Mediated Macrophage Pyroptosis.

Jiao Yue, Peng Wang, Hao Liu, Haifeng Pei

Abstract read
In one paragraph

Article in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiao YueDepartment of Cardiology, The General Hospital of Western Theater Command, College of Medicine Southwest Jiaotong University Chengdu Sichuan China.
Peng WangDepartment of Cardiology, The General Hospital of Western Theater Command, College of Medicine Southwest Jiaotong University Chengdu Sichuan China.
Hao LiuDepartment of Cardiology, The General Hospital of Western Theater Command, College of Medicine Southwest Jiaotong University Chengdu Sichuan China.
Haifeng PeiDepartment of Cardiology, The General Hospital of Western Theater Command, College of Medicine Southwest Jiaotong University Chengdu Sichuan China.ORCID https://orcid.org/0000-0003-1502-8404

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the therapeutic effects of Poncirin on hypoxic pulmonary hypertension (HPH) and to elucidate the underlying mechanism, with a specific focus on transactive response DNA-binding protein 43 (TDP43)-mediated macrophage pyroptosis. A rat model of HPH was established using a hypobaric hypoxia chamber. In vitro, rat alveolar macrophages (NR8383 cells) and pulmonary artery smooth muscle cells (PASMCs) were cultured under normoxic or hypoxic (1% O

Indexed as

hypoxic pulmonary hypertensionPoncirinpyroptosisTAR DNA binding protein‐43

Identifiers

PMID42516677
PMCPMC13404783

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.