ArticleIJU case reports2026
Multimodal Treatment for Female Primary Urethral Carcinoma: A Three-Case Series Utilizing Robot-Assisted Radical Cystectomy and Extended Resection.
Article in IJU case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Primary urethral carcinoma (PUC) is a rare malignancy, particularly in females, with no established standard treatment. We herein examined the clinical outcomes of three female patients who underwent multimodal therapy with robot-assisted radical cystectomy (RARC) and extended surgical resection. Case Presentation: Three female patients (45, 65, and 71 years) were diagnosed with PUC (adenocarcinoma, cT3N0M0; clear cell carcinoma, cT3N2M0; and squamous cell carcinoma, cT4N0M0). Two patients received cisplatin-based neoadjuvant chemotherapy. All patients underwent RARC with en bloc urethrectomy and extended resection of the anterior vaginal wall or pelvic fascia. One achieved a pathological complete response, one developed local recurrence due to a positive surgical margin, and two remained recurrence-free. Conclusion: Individualized multimodal strategies combining perioperative chemotherapy and extended surgical resection are crucial for managing locally advanced PUC in females.
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