Integrated lumped parameter modeling of cardiac-vascular interaction with valve dynamics and ventricular pressure-volume.

Introduction: Lumped-parameter cardiovascular models provide a useful framework for analyzing cardiac hemodynamics and valve-related flow disturbances. In this study, a lumped-parameter model was developed to investigate the hemodynamic response of the left ventricle and its interaction with aortic valve dynamics under physiological and pathological conditions. Methods: The model incorporated time-varying ventricular elastance, valve flow relations, and vascular resistance-compliance effects to simulate pressure, flow, and volume variations over a cardiac cycle. The predicted waveforms were compared with a reference model to evaluate arrangement in magnitude, waveform shape, and phase synchronization. A systematic sensitivity analysis was also performed to assess the effects of arterial compliance (C Results: The predicted pressure, flow, and volume waveforms showed good agreement with the reference model in terms of magnitude, waveform pattern, and timing. Arterial compliance had only a minor effect on both SV and ΔP Discussion: The findings demonstrated that vascular compliance, myocardial elastance, and valve geometry contributed differently to cardiovascular dynamics. The model also showed that lumped-parameter approaches can be used to study ventricular-valvular interaction and may support diagnostic analysis and patient-specific cardiovascular assessment.