Evidence map›Paper›PMID 42516389›Full record

ArticleFrontiers in immunology2026

Berberine alleviates biofilm-associated immune-inflammatory injury in

Xuan Deng, Lin Zhang, Jinglin Li, Fuyin Yang, Chengrui Peng, Jiaze Peng, Yang Yu, Xianpeng Huang, Xuxu Yang, Lidan Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xuan Deng *Department of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Lin Zhang *Department of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Jinglin LiDepartment of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Fuyin YangDepartment of Orthopedics Center, Renhuai People's Hospital, Zunyi, China.
Chengrui PengDepartment of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Jiaze PengDepartment of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Yang YuDepartment of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Xianpeng HuangDepartment of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Xuxu YangDepartment of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Lidan YangDepartment of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: An Results: BBR significantly reduced bacterial viability within biofilms and decreased CFU counts Conclusion: These findings suggest that BBR exerts protective effects against SA-induced OM through antibiofilm and anti-inflammatory activities. However, its antibacterial efficacy was weaker than that of CLD, indicating that BBR should not be regarded as a replacement for antibiotics but rather as an adjunctive therapy for biofilm-associated osteomyelitis.

Indexed as

Anti-Inflammatory AgentsBerberineBiofilmsOsteomyelitisStaphylococcal InfectionsStaphylococcus aureusAnimalsAnti-Bacterial AgentsDisease Models, AnimalMaleMiceMolecular Docking SimulationNetwork PharmacologyAnti-Bacterial AgentsAnti-Inflammatory AgentsBerberineberberinebiofilmHIF-1αosteomyelitisPTGS2Staphylococcus aureus

Identifiers

PMID42516389
PMCPMC13402166

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.